Teaching an old drug new tricks to fight cytomegalovirus


An old drug once mostly used to treat amebiasis — a disease caused by a parasite — and induce vomiting in cases of poisoning appears to also halt replication of cytomegalovirus (CMV), a herpesvirus that can cause serious disease in immunocompromised individuals, including those with HIV or organ transplant recipients, report researchers.

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A large percentage of women with cirrhosis experience abnormal uterine bleeding, which may be due to the coagulopathy that accompanies liver disease, or endometrial hyperplasia or carcinoma. Although hysterectomy is the criterion standard of treatment for atypical endometrial hyperplasia in a postmenopausal woman, patients with cirrhosis severe enough to require transplant are usually poor surgical candidates. Multiple studies have shown success with conservative management of atypical hyperplasia. There is a paucity of literature on managing patients undergoing transplant with abnormal uterine bleeding and …

Source: MenopauseCategory: OBGYN Tags: Case Report Source Type: research

ConclusionsOrgan donation, where permitted, had limited impact on autopsy evidence and any subsequent court proceedings. Where organ donation was not permitted, autopsy evidence did not significantly alter coronial findings or judicial outcomes.

According to a recent study, many of the deceased-donor kidneys discarded in the United States would be safely transplanted in France.Medscape Medical News

Bioengineers and dentists from the UCLA School of Dentistry have developed a new hydrogel that is more porous and effective in promoting tissue repair and regeneration compared to hydrogels that are currently available. Once injected in a mouse model, the new hydrogel is shown to induce migration of naturally occurring stem cells to better promote bone healing. Current experimental applications using hydrogels and stem cells introduced into the body or expensive biological agents can come with negative side effects.The findings, published online in the journal Nature Communications, suggest that in the near future the…

We describe the case of a 11-year-old patient with intestinal occlusion, surgically treated with intestinal volvulus, the surgical specimen is sent to histopathology reporting Chagasic megacolon. The age range of presentation is a challenge in the absence of nonspecific symptoms. There is no pediatric statistical data that define trypanosomiasis in a latent or chronic state and will be diagnosed in adult stages due to the physiopathological alterations that they will present.
PMID: 31448790 [PubMed – in process]

Source: Cirugia y CirujanosCategory: Surgery Authors: Tags: Cir Cir Source Type: research

ConclusionsOur data show, for the first time, that the intestinal microbiota can induce insulin resistance and obesity in an animal model that is genetically protected from these processes.

Source: Life SciencesCategory: Biology Source Type: research

HIV infection increases the risk of cancer. HIV-associated lymphocytopenia and immune dysregulation permit immune evasion of oncogenic viruses and premalignant lesions. Various types of immunotherapy, including monoclonal antibodies, interferon, cytokines, immunomodulatory drugs (IMiDs), allogeneic hematopoietic stem cell transplant, and most importantly ART have shown efficacy in HIV-related cancer. Emerging data suggest that checkpoint inhibitors targeting the PD-1/PD-L1 pathway can be safe and effective in people with HIV and cancer. Cancer immunotherapies may also affect HIV latency reversal, HIV-specific immunity, and…

This report shows that intraflap anastomoses for two different pedicles can be u seful for no more than one artery and vein at the recipient site and also allows for preservation of the other lateral circumflex branches.Level of evidence: Level V, therapeutic study.

Using “synthetic pot” is rolling the dice with your health, experts warn, pointing to a healthy 26-year-old woman who ended up in the ER after smoking a batch laced with rat poison.

Source: WebMD HealthCategory: Consumer Health News Source Type: news

Between 2004 and 2014, U.S. transplant centers discarded about 18% of over 156,000 deceased-donor kidneys recovered, about two times higher than the discard rate in France.

Source: WebMD HealthCategory: Consumer Health News Source Type: news

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