Review of appendix cancer cases finds over diagnosis

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(University of California – San Diego) Lesions of the appendix are being over diagnosed as invasive cancer, report University of California San Diego School of Medicine researchers in a paper published June 7 in the journal PLOS ONE.

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Authors: Kajiyama H, Suzuki S, Utsumi F, Nishino K, Niimi K, Mizuno M, Yoshikawa N, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Shibata K, Nagasaka T, Kikkawa F
Abstract
Malignant ovarian neoplasm is one of the most lethal malignancies among cancers of the female reproductive system. Occasionally, these tumors originate from non-ovarian organs as metastatic lesions since the ovary is a frequent metastatic target of many cancers. However, there limited clinical information on metastatic ovarian carcinoma (MOC) and its hallmarks are unknown. During the period of 1986-2015, 4,284 patients with malignant ovarian neoplasm …

ConclusionGoblet cell carcinoma of the appendix is very rate. It tends to seed throughout the peritoneum, making aggressive surgical cytoreduction and chemotherapy viable treatment options. Investigation into the molecular basis of these tumors may improve the diagnosis, prognosis and therapeutic decisions regarding these patients. ∆Np73 seems a good candidate for further analysis in longer series.

Abstract
One potential harm of nonoperative management for acute appendicitis is missed appendiceal cancer, a rare and often aggressive malignancy due to the frequency of late stage of diagnosis. Previous studies have reported an increasing incidence of appendiceal neoplasms in the population. This is a retrospective case-control study of 1007 adult patients, who presented to the University of North Carolina-Memorial Hospital (UNC-MH) between 2011 and 2015 with clinical signs and symptoms of appendicitis. We evaluated the incidence of primary appendiceal cancer in this population and determined factors that predic…

Source: The American SurgeonCategory: Surgery Authors: Tags: Am Surg Source Type: research

Conclusions: Staging classification is updated regularly, which clinicians should always catch up with.
PMID: 30608547 [PubMed – as supplied by publisher]

Source: Clinical Colorectal CancerCategory: Cancer & Oncology Authors: Tags: Jpn J Clin Oncol Source Type: research

(Wake Forest Baptist Medical Center) Scientists at the Wake Forest Institute for Regenerative Medicine have recently developed a process that may change the way cancer of the appendix is treated in the future.

Appendix cancer is very rare, and many people experience no symptoms in the early stages. Doctors often diagnose this cancer when it spreads to other organs or after they remove a person ’s appendix due to appendicitis. Learn more here.

This study analyzed clinical outcomes of high-grade AC after CRS/HIPEC.MethodsA prospective database of CRS/HIPEC procedures for HGMCP performed from 1998 –2017 was reviewed. Perioperative variables and survival were analyzed.ResultsEighty-six HGMCP and 65 HGMCP-S were identified. HGMCP had more positive tumor markers (TM) (CEA/CA-125/CA-19-9) than HGMCP-S (63% vs 40%,p = 0.005). HGMCP had higher Peritoneal Cancer Index (32 vs 26,p = 0.097) and was less likely to have positive lymph nodes (LN) than HGMCP-S (28% vs 69%,p = 

ConclusionThis is the first case report of appendiceal cancer with an ileal fistula that successfully treated with laparoscopic resection. Laparoscopic ileocecal resection can be applied for appendiceal cancers with a fistula by experienced surgeons with careful consideration.

No abstract available

Source: Oncology TimesCategory: Cancer & Oncology Tags: News Source Type: research

(University of California – San Diego) To understand why some patients with appendix cancer respond to standard treatment while others do not, University of California San Diego School of Medicine and Moores Cancer Center researchers, in collaboration with Foundation Medicine, performed genetic profiling on 703 appendiceal tumors — the largest such study of this disease to date — to compare mutations present in both cancer types.



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