In collaboration withEurope PMC, PMC has rolled out
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Breast cancer patients have a higher mortality risk of cardiovascular disease (CVD) than women from the general population. CVD risk may increase significantly in postmenopausal women with early-stage breast cancer. The aim of this study was to evaluate risk factors for CVD in postmenopausal breast cancer survivors.
In this cross-sectional study, 96 postmenopausal breast cancer survivors were compared with 192 postmenopausal women. The main group included women with amenorrhea>12 months, aged ≥45 years, with breast cancer, and without established CVD. The control group fulfilled the same crit…
To assess the effects of vaginal erbium laser treatment on the vaginal health and sexual function of postmenopausal women with a history of breast cancer.
An open, prospective, therapeutic intervention study was conducted with 24 postmenopausal women with a history of breast cancer and vaginal dryness, and/or dyspareunia, who had not used vaginal hormone therapy for at least 6 months. The women were treated using a 2,940-nm Erbium: YAG laser (Etherea-MX, Athena, São Carlos, São Paulo, Brazil), with 90o and 360o scanning scopes, between August, 2017 and October, 2017 in a private clin…
Ovarian cancer is a common gynecologic malignancy with a poor prognosis and a lack of screening for women at average risk. Focus has therefore shifted toward strategies for risk-reducing surgery to prevent the development of ovarian cancer. This Practice Pearl describes the evidence supporting opportunistic salpingectomy at the time of hysterectomy or tubal sterilization as a strategy to reduce the risk of ovarian cancer, the risks and benefits associated with the procedure, and the methods used.
BOWEL cancer is one of the most common forms of cancer diagnosed in the UK. Outlook depends on the stage of the cancer when it is diagnosed. Knowing the warning signs is imperative.
Authors: Viale G, Morganti S, Ferraro E, Zagami P, Marra A, Curigliano G
INTRODUCTION: Despite dramatic improvements in survival achieved with currently available anti-HER2 agents, HER2 positive metastatic breast cancer remains an almost invariably deadly disease, with primary or acquired resistance to HER2 directed agents developing during course treatment. Many efforts are focused on identifying new agents that may more effectively inhibit HER2 signaling and on possible combination strategies. Areas covered: This review summarizes the landscape of drugs under development for HER2 positive metastatic brea…
Authors: Mormile R
PMID: 31446811 [PubMed – as supplied by publisher]
AbstractWnt signaling has been implicated in numerous aspects of development, cell biology, and physiology. When aberrantly activated, Wnt signaling can also lead to the formation of tumors. Thus, Wnt signaling is an attractive target for cancer therapy. Based on our screening program targeting Wnt signaling activity using a cell-based luciferase screening system assessing TCF/ β-catenin transcriptional activity, we isolated a series of terpenoids and heterocyclic aromatic compounds that affect the Wnt signaling pathway at different points. Here, we describe our recent results in screening for natural products that in…
Liver resection for nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is associated with favorable long-term survival but with more surgical morbidity and post-hepatectomy liver failure, compared with non-NAFLD HCC, researchers from Singapore report.Reuters Health Information
A backlash is growing against the Tennessee Valley Authority over the nation’s worst coal ash spill a decade ago, as cleanup workers say they have contracted cancers and lung diseases
This article explores the known and the emerging areas of clinical research on patients with BRCAwt ovarian cancer. Expert opinion: Discovery of molecular changes tied to annotated disease information, along with an expanding array of pathway targets and targeted therapeutic agents, creates optimism and opportunity for women with ovarian cancer. Using precision oncology approaches, clinical researchers are, and will be, poised to select more effective treatments for ovarian cancer patients.
PMID: 31449760 [PubMed – as supplied by publisher]