Radiation-induced Angiosarcoma of the Breast Radiation-induced Angiosarcoma of the Breast


Was this patient’s angiosarcoma due to her previous chest-wall radiation?Applied Radiology

Source: Medscape Today HeadlinesCategory: Consumer Health News Tags: Radiology Journal Article Source Type: news

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We present a case of an undifferentiated subtype of non-keratinizing squamous cell carcinoma (NK-SCC) with sarcomatoid features in the nasopharynx in a 69-year-old man who was difficult to diagnose due to spindle-shaped malignant cells. He was admitted because of a right nasal obstruction and right headache, and imaging revealed a heterogeneously enhanced irregularly shaped mass at the nasopharynx. Histopathologically, the tumour was partially organised, and the tumour cells were epithelioid or spindle-shaped. Initially, we erroneously diagnosed the tumour as an angiosarcoma owing to its false-negative immunoreaction for c…

We report our experience of combined chemo- and radiotherapy in the clinical course of 6 patients with cutaneous angiosarcoma who were treated between 2007 and 2018.
RESULTS: All patients presented non-resectable tumours and were treated with radiotherapy in combination with the administration of liposomal, pegylated doxrubicin (25 mg/m2 every 2 weeks). The mean duration of progression-free survival was 8 months (5-14 months), corresponding to an overall survival of 13 months (13-34 months). A partial response was seen in 4 patients and 1 patient developed progressive dise…

Introduction: Cutaneous angiosarcoma (CAS) is a rare, malignant tumor of vascular mesenchymal origin accounting for

AbstractBackgroundPrimary cardiac angiosarcoma (PCAS) is a rare type of tumour. Furthermore, descriptions of the demographic features and prognostic factors of PCAS patients have been poorly reported.MethodsA population cohort study was conducted using retrospectively extracted data from the SEER (Surveillance, Epidemiology and End Results) database for patients with histological diagnoses of PCAS; the extracted information included demographic, treatment and outcome data.ResultsA total of 168 cases of PCAS from 1973 to 2013 were included. The mean age at diagnosis was 44.4  ± 15.5 years. PCAS was…

Within the context of the presented case, the patient likely developed radiation-associated angiosarcoma (RAA).1 The timeframe fits because most cases of RAA occur between 2 to 12  years postradiation. Additionally, the clinical features are consistent with RAA, which usually develops in the dermis of the radiated skin. In contrast, primary angiosarcoma more commonly develops in the breast parenchyma.2 We counsel patients who present for postoperative radiation to the breast that the risk of developing radiation-induced malignancy in the treatment field is about 1 in 1000 to 1 in 10,000 over 10 years.

Angiosarcoma (AS) develops in various soft tissues and organs, but the most frequently affected site is the skin, commonly occurring in the scalp of elderly people and typically presenting as an enlarging bruise-like purpura [1 –5]. In the most of patients, AS is relatively large at the time of diagnosis because of a significant delay in diagnosis. There are some treatment options, however, an effective treatment has not been established yet, resulting in the poor prognosis.

Source: Journal of Dermatological ScienceCategory: Dermatology Authors: Source Type: research

Scalp angiosarcoma is a rare and highly aggressive cutaneous malignancy with poor prognosis and high recurrence rate. Multimodality approach is currently the treatment protocol for resectable angiosarcoma, including wide local excision and post-operative radiation. This single-institution study reviews the 18-year experience of the surgical treatment of scalp angiosarcomas.

ConclusionsThis case series underscores the value of targeted immunotherapy in treating angiosarcoma. It also identifies genetic heterogeneity of cutaneous angiosarcomas and discusses specific genetic findings that may explain reported benefits from immunotherapy.

ConclusionPreliminary results in a limited number of patients proved directional atherectomy beneficial as a safe and feasible technique for endoluminal tissue sampling of vascular masses. Additional large-scale studies are necessary and worthy for further evaluation in clinical practice.Key Points• Endovascular masses pose a challenge to appropriate clinical management.• Off-label directional atherectomy proved to be a safe and feasible technique for endoluminal tissue sampling of vascular masses. Furthermore, directional atherectomy was superior to aspiration or forceps biopsy in our small study cohort.• D…

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