radiologic and pathologic distinctions of a kidney cancer mimic

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Anastomosing hemangioma (ah) is a rare subtype of primary vascular tumour that can, clinically and radiologically, present similarly to malignant renal tumours such as renal cell carcinoma (rcc) and angiosarcoma.07/12/2018

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CONCLUSION: Patients with non-cancer symptoms are frequently referred with suspected cancer. Patients with red flag symptoms are not aware of their significance and they have low expectations of healthcare.
PMID: 31439066 [PubMed – as supplied by publisher]

Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Jinyang Chen, Yan Wu, Cuicui Fu, Haiyan Cao, Xiaoping Tan, Wenbing Shi, Zhaoyang WuAbstractMicroRNAs (miRNAs) serve as significant regulators in a variety of diseases and have been emerging as a class of promising biomarkers for early cancer diagnosis. Herein, an enzyme-free surface-enhanced Raman scattering (SERS) platform was proposed for sensitive and reliable detection of target miRNA-21 using a corrective internal standard (IS)-based ratiometric SERS probe coupled with mismatched catalytic hairpin assembly (CHA) amplification….

Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Moslem Afzali, Ali Mostafavi, Tayebeh ShamspurAbstractDespite its useful properties, imiquimod (IMQ), known as an anti-cancer drug, can be harmful to the skin at high concentrations. Therefore, we have developed a novel electrochemical sensor to determine IMQ, for the first time. A glassy carbon electrode (GCE) was modified by a new composite comprising of ionic liquid-based molecularly imprinted polymer (MIP) and gold nanoparticles/graphene oxide (Au/GO). The MIP/Au/GO nanocomposite was synthesized through non-covalent imprinting …

Publication date: Available online 23 August 2019Source: MethodsAuthor(s): Jianji Chen, Cari Sagum, Mark T BedfordAbstractSignal transduction is driven by protein interactions that are controlled by posttranslational modifications (PTM). Usually, protein domains are responsible for “reading” the PTM signal deposited on the interacting partners. Protein domain microarrays have been developed as a high throughput platform to facilitate the rapid identification of protein-protein interactions, and this approach has become broadly used in biomedical research. In this review, we will summarize the history, developme…

Source: MethodsCategory: Molecular Biology Source Type: research

Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Di Wu, Liang Guo, Si-Jie LiAbstractTwo Schiff base ligands 2-((ethylamino)methyl)-6-methoxyphenol (HL1) and (E)-2-(((2-(dimethylamino)ethyl)imino)methyl)-6-methoxyphenol (HL2) with bi-nucleating or tri-nucleating mode have been successfully prepared via an one step organic condensation reaction, which were further applied in the synthesis of three new Cu(II) and Ni(II)-based coordination complexes [Cu(L1)2](EtOH) (1), [Ni(L1)2](EtOH) (2) and [Cu(L2)(HL2)(SCN)](MeOH)2 (3). Furthermore, a hand grinding technique has been used to dec…

This study was done by collecting wild PU and cultivated PU and compared with a counterfeit which is commonly found in the market. Fourier Transform Infrared (FTIR) and Two-Dimension Infrared (2DIR) for the qualitative analysis are often regarded as green methods because the original resources of the test sample are preserved. The different spectral patterns of the counterfeit PU compared with the genuine PU were clearly indicated in 1D FTIR spectrum. The 2DIR spectrum of counterfeit PU showed more than 70% dissimilarity compared to genuine PU. This rapid and simple sample preparation enhances the speed of qualitative anal…

Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Yu-Ying Tian, Zhi-Guo Xin, Hai-Feng Hou, Xiao-Chun Zhu, Qian Guo, Qin XiaoAbstractTwo new Cu(II)-containing coordination complexes with the chemical formulae of [Cu2(pydc)2(H2O)2]n (1, pydc = 3,5-pyridinedicarboxylate) and {[Cu(H2O)2(H3hmidc)2](H2O)}n (2, H4hmidc = 2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylic acid) have been successfully synthesized and characterized under solvothermal conditions. The in vitro anti-tumor activities of compounds 1 and 2 were studied on human atrial myxoma cell HemECs. The WST-8 as…

In this study; spectroscopic, electronic and biological properties of Boc-D-Lys-OH (BDLO) molecule have been examined using quantum chemical calculations. First of all, the molecule was optimized and geometric structure parameters and vibrational wavenumbers were calculated by DFT/ B3LYP methods 6-311G++(d,p) basis set. The calculated wavenumbers were then compared with the experimental values of the FT-IR and FT-Raman spectra. Finally, the molecular docking was determined for anti apoptotic proteins with BDLO molecule. The results showed Boc-D-Lys-OH molecule had more binding affinity with AKT1 and concluded this molecule…

Publication date: Available online 24 August 2019Source: Journal of Molecular StructureAuthor(s): Javed Iqbal, Banzeer Ahsan Abbasi, Riaz Ahmad, Amir Shahbaz, Syeda Anber Zahra, Sobia Kanwal, Akhtar Munir, Atiya Rabbani, Tariq MahmoodAbstractThis present study for the first time reports a facile and ecofriendly route for synthesis of IONPs. The IONPs were simply synthesized using Rhamnella gilgitica leaves extract as both reducing and stabilizing agents. The color change of the reaction mixture from dark brown to reddish black determined the biofabrication of IONPs which was further confirmed by the presence of an absorban…

Publication date: Available online 23 August 2019Source: Journal of Molecular StructureAuthor(s): Rahman Abdizadeh, Farzin Hadizadeh, Tooba AbdizadehAbstractHistone deacetylases (HDACs) as the promising therapeutic targets for the treatment of cancer and other diseases, modify chromatin structure and contribute to aberrant gene expression in cancer. Inhibition of HDACs is emerging as an important strategy in human cancer therapy and HDAC inhibitors (HDACIs) enable histone to maintain a high degree of acetylation. In this work, molecular modeling studies, including CoMFA, CoMFA-RF, CoMSIA and HQSAR and molecular docking wer…



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