Western medicine is ill-equipped to handle parasites: Standard treatments are ineffective and often lethal

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(Natural News) A study published in the journal Nature Communications revealed that sleeping sickness, clinically known as African trypanosomiasis, not only affects the circadian rhythm but may also impact a wide range of important body functions. According to the experts, the disease can be transmitted through the bite of the tsetse fly. The scientists added that that condition…

Source: NaturalNews.com – July 14, 2018Category: Consumer Health News Source Type: news

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Publication date: Available online 1 August 2019Source: Protein Expression and PurificationAuthor(s): Lauren E-A. Eyssen, Theresa H.T. CoetzerAbstractThe metacaspases (MCAs) are attractive drug targets for the treatment of African trypanosomiasis as they are not found in the metazoan kingdom and their action has been implicated in cell cycle and cell death pathways in kinetoplastid parasites. Here we report the biochemical characterisation of MCA5 from T. congolense. Upon recombinant expression in E. coli, autoprocessing is evident, and MCA5 further autoprocesses when purified using nickel affinity chromatography, which we…

Wow – we received so many excellent comments on how parasites and the number 5 go together! Here are many of them – in no particular order – for your viewing pleasure:Pentatrichomonas hominis is a nonpathogenic intestinal flagellate named for its 5 flagella (penta from the Greek pente, meaning five + trich, pertaining to hair [flagella]). By Neil Anderson and Bernardino Rocha.There are 5 lobes of the lung, and all can be infected by Paragonimusspecies. By Brian Duresko.The are 5Plasmodiumspecies that are responsible for the bulk of malaria in humans:P. falciparum, P. vivax, P. ovale, P. malariae, andP. knowlesi(t…

by Daniela I. Schneider, Norah Saarman, Maria G. Onyango, Chaz Hyseni, Robert Opiro, Richard Echodu, Michelle O ’Neill, Danielle Bloch, Aurélien Vigneron, T. J. Johnson, Kirstin Dion, Brian L. Weiss, Elizabeth Opiyo, Adalgisa Caccone, Serap Aksoy Tsetse flies (Glossina spp.) are vectors of parasitic trypanosomes, which cause human (HAT) and animal African trypanosomiasis (AAT) in sub-Saharan Africa. In Uganda,Glossina fuscipes fuscipes (Gff) is the main vector of HAT, where it transmits Gambiense disease in the northwest and Rhodesiense disease in central, southeast and western regions. Endosymbionts can infl…

Publication date: Available online 29 July 2019Source: Biochimica et Biophysica Acta (BBA) – Molecular Cell ResearchAuthor(s): Vishal C. Kalel, Mengqiao Li, Stefan Gaussmann, Florent Delhommel, Ann-Britt Schäfer, Bettina Tippler, Martin Jung, Renate Maier, Silke Oeljeklaus, Wolfgang Schliebs, Bettina Warscheid, Michael Sattler, Ralf ErdmannAbstractTrypanosomatid parasites cause devastating African sleeping sickness, Chagas disease, and Leishmaniasis that affect about 18 million people worldwide. Recently, we showed that the biogenesis of glycosomes could be the “Achilles’ heel” of trypanosomatids suitable …

Antitrypanosomal Effects of Zanthoxylum zanthoxyloides (Lam.) Zepern. &Timler Extracts on African Trypanosomes. Evid Based Complement Alternat Med. 2019;2019:1730452 Authors: Dofuor AK, Djameh GI, Ayertey F, Bolah P, Amoa-Bosompem M, Kyeremeh K, Okine LK, Gwira TM, Ohashi M Abstract African trypanosomiasis is a disease caused by the parasitic protozoa of the Trypanosoma genus. Despite several efforts at chemotherapeutic interventions, the disease poses serious health and economic concerns to humans and livestock of many sub-Saharan African countries. Zanthoxylum zanthoxyloides (Lam.) Zepern. &T…

ino D Abstract Searching for a more effective chemotherapy for the treatment of Human African trypanosomiasis, the disease caused by the parasite Trypanosoma brucei, and cancer, in the current work five new [PtII(L)(dppf)](PF6) compounds, with HL = 8-hydroxyquinoline derivatives and dppf = 1,1′-bis(diphenylphosphino)ferrocene, were synthesized and fully characterized. Crystal structures of three compounds were solved by XRD. The compounds displayed fairly good activity against bloodstream T. brucei, with IC50 values in the submicromolar range (IC50: 0.14-0.93 μM), and good selectivity towards the path…

Source: Journal of Inorganic Biochemistry – July 16, 2019Category: Biochemistry Authors: Rivas F, Medeiros A, Comini M, Suescun L, Rodríguez Arce E, Martins M, Pinheiro T, Marques F, Gambino D Tags: J Inorg Biochem Source Type: research

Abstract More than 10 million people around the world are afflicted by Neglected Tropical Diseases, such as Chagas Disease, Human African trypanosomiasis, and Leishmania. These diseases mostly occur in undeveloped countries that suffer from a lack of economic incentive, research, and policy for new compound development. Sulfonamide moieties are effective scaffolds present in several compounds that are determinants to treat various diseases, principally neglected tropical diseases This review article examines the contribution of these scaffolds in medicinal chemistry in the last five years, focusing on three trypan…

Source: Medicinal Chemistry – June 20, 2019Category: Chemistry Authors: Scarim CB, Chelucci RC, Dos Santos JL, Chin CM Tags: Med Chem Source Type: research

AbstractHuman African trypanosomiasis (HAT), also known as sleeping sickness, is one of the Africa’s ‘neglected diseases’ and is caused by infection with protozoan parasites of theTrypanosoma genus. Transmitted by the bite of the tsetse fly, it puts 70 million people at risk throughout sub-Saharan Africa and is usually fatal if untreated or inadequately treated. In this brief overview, some important recent developments in this disease are outlined. These cover various aspects including a reduction in disease incidence, newly recognised parasite reservoir sites in humans, disease outcome, novel diagnostic methods, new and …

ConclusionsIn this paper we discuss the current state of the results and draw on evidences from malaria, dengue and other vector-borne diseases to illustrate the state of current thinking and outline the need for further research to inform our predictions and response.

In this study, the STLs α-santonin, arglabin, schkuhrin II, vernolepin, and eucannabinolide, all trypanocides, were loaded into polylactic acid (PLA) NPs through an emulsification-diffusion method. The NPs were stable, homogenous, and spherical in shape with a rounded knotty depression like a navel orange. The average particle sizes were 202.3, 220.3, 219.5, 216.9, and 226.4 nm for α-santonin, arglabin, schkuhrin II, vernolepin, and eucannabinolide, respectively. The NPs had encapsulation efficiencies of 94.6, 78.1, 76.8, 60.7, and 78.9% for α-santonin, arglabin, schkuhrin II, vernolepin, and eucannabinol…

Source: Molecules – June 4, 2019Category: Chemistry Authors: Njogu Kimani Solveig Backhaus Josphat Matasyoh Marcel Kaiser Fabian Herrmann Thomas Schmidt Klaus Langer Tags: Article Source Type: research



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