Managing Acinetobacter baumannii Infections Managing Acinetobacter baumannii Infections


A. baumannii is commonly involved in nosocomial infections, but few therapeutic options are available. Find out what there is to know.Current Opinion in Infectious Diseases

Source: Medscape Today HeadlinesCategory: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

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Environmental Science&TechnologyDOI: 10.1021/acs.est.9b01206

Source: Environmental Science and TechnologyCategory: Environmental Health Authors: Source Type: research

This study highlights the important roles of TLRs in A. baumannii OMV-induced pulmonary inflammation in vivo.

Source: Infection and ImmunityCategory: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research

Light is an environmental signal that produces extensive effects on the physiology of the human pathogen Acinetobacter baumannii. Many of the bacterial responses to light depend on BlsA, a blue-light- using FAD (BLUF)-type photoreceptor, which also integrates temperature signals. In this work, we disclose novel mechanistic aspects of the function of BlsA. First, we show that light modulation of motility occurs only at temperatures lower than 24ºC, a phenotype depending on BlsA. Second, blsA transcript levels were significantly reduced at temperatures higher than 25ºC, in agreement with BlsA protein levels in the …


Source: Infectious DiseasesCategory: Infectious Diseases Authors: Source Type: research

Publication date: Available online 19 August 2019Source: Microbial PathogenesisAuthor(s): Aoyun Li, Yaping Wang, Lulu Pei, Khalid Mehmood, Kun Li, Hammad Qamar, Mudassar Iqbal, Muhammad Waqas, Juanjuan Liu, Jiakui LiAbstractYaks are an aboriginal breed of the Qinghai-Tibet plateau (3000 m), which are highly adaptable to cold and hypoxic environments. It is noticed that hypoxia and hypothermia can induce changes in intestinal microbial structure in animals. Increasing evidences suggested that probiotics supplementation can improve the balance of gut microbiota of animals. However, so far, very few studies have emphasized …

Authors: Koyuncu Özyurt Ö, Özhak B, Öğünç D, Yıldız E, Çolak D, Günseren F, Öngüt G
Infections with multidrug resistant gram-negative bacteria is a growing problem especially in health care settings. Colistin is one of the last resort antibiotics for such infections in which treatment options are limited. Increasing resistance to colistin is a global problem. Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) study groups have recommended the ISO-standard broth microdilution …

Source: Mikrobiyoloji BulteniCategory: Microbiology Tags: Mikrobiyol Bul Source Type: research

Publication date: Available online 15 August 2019Source: Biochemical Engineering JournalAuthor(s): Li Xia, Xiaotong Luo, Yunfei Zhu, Xiang Zhang, Lixin LuoAbstractApplications of immobilization technology to wastewater treatment have achieved mixed results, that is, high degradation efficiency or good reusability. In this research, alginate was used as supporting material of immobilized beads to maintain high degradation efficiency. Applying CaCl2 freeze drying and acidic solutions led to the reusability of the beads. Ca-alginate beads can be reused for more than 21 cycles of repeated CaCl2 freeze drying and 16 cycles of t…

Michael Wink

Infections caused by multidrug-resistant bacteria are a global emerging problem. New antibiotics that rely on innovative modes of action are urgently needed. Ranalexin is a potent antimicrobial peptide (AMP) produced in the skin of the American bullfrog Rana catesbeiana. Despite strong antimicrobial activity against Gram-positive bacteria, ranalexin shows disadvantages such as poor pharmacokinetics. To tackle these problems, a ranalexin derivative consisting exclusively of d-amino acids (named danalexin) was synthesized and compared to the original ranalexin for its antimicrobial potential and its bi…

Source: MoleculesCategory: Chemistry Authors: Tags: Article Source Type: research

This study aimed to isolate and characterize bacterial endophytes and their crude extracts fromC.  macowanii bulbs. Endophytes were isolated using validated surface sterilization techniques, followed by phenotypic and genotypic profiles of the isolates. Crude extracts were extracted from the endophytes using ethyl acetate, while methanol:dichloromethane (1:1) was used to obtain crude extracts from the bulbs. Antibacterial activity of crude extract from each endophyte was investigated against selected pathogenic strains using the broth microdilution method, and anticancer activity against U87MG glioblastoma and A549 lu…

Source: MicrobiologyOpenCategory: Microbiology Authors: Tags: ORIGINAL ARTICLE Source Type: research

Chaitra Shankar, Agila Kumari Pragasam, Balaji Veeraraghavan, Anushree AmladiIndian Journal of Medical Microbiology 2019 37(1):91-94
Tigecycline is a reserve antibiotic increasingly used for the treatment of multidrug-resistant bacteria, especially Klebsiella pneumoniae and Acinetobacter baumannii. At present, there are concerns regarding the testing and interpretation of tigecycline susceptibility to bugs such as K. pneumoniae and A. baumannii, which limit clinicians in appropriate usage. Use of appropriate method for testing such as broth microdilution is essential. In addition, tigecycline susceptibility testing is a c…

Source: Indian Journal of Medical MicrobiologyCategory: Microbiology Authors: Source Type: research

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