First major study of proteins in patients with acute lymphoblastic leukaemia


(Lund University) The most common form of childhood cancer is acute lymphoblastic leukaemia (ALL). Researchers at Lund University in Sweden, in cooperation with Karolinska Institutet, SciLifeLab and the University of Cambridge, have now carried out the most extensive analysis to date of ALL at the protein level, by studying the activity in over 8 000 genes and proteins. The results show aberrant folding in the DNA string, which in turn affects the genes’ activity. The study was recently published in Nature Communications.

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DiscussionWe estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.

Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood…

Source: BMC CancerCategory: Cancer & Oncology Authors: Tags: Research article Source Type: research

Authors: Rahmani M, Fardi M, Farshdousti Hagh M, Hosseinpour Feizi AA, Talebi M, Solali S
Background: Ikaros family zinc finger 1 (IKZF1) is a transcription factor with an important role in controlling hematopoietic proliferation and function, particularly lymphoid cell differentiation. It was previously shown that various mechanisms and expression patterns of Ikaros are linked to a variety of cancers. We hypothesized that aberrant methylation (hypomethylation) of the IKZF1 promoter region might be one of the causes of B-cell acute lymphoblastic leukemia (B-ALL). In B-ALL patients, an increased expression …

Source: Blood ResearchCategory: Hematology Tags: Blood Res Source Type: research

In this study,TCF3 ‐HLF mRNA was detectable at a high level during induction therapy in a newly diagnosed t(17;19) ‐ALL case, whileTCF3 ‐PBX1 mRNA was undetectable at the end of induction therapy in most newly diagnosed t(1;19) ‐ALL cases. Using 4 t(17;19)‐ALL and 16 t(1;19)‐ALL cell lines, drug response profiling was analyzed. t(17;19)‐ALL cell lines were found to be significantly more resistant to vincristine (VCR), daunorubicin (DNR), and prednisolone (Pred) than t(1;19)‐ALL cell lines. Sensitivities to three (Pred, VCR, andl‐asparaginase [l‐Asp]), four (Pred, VCR,l‐Asp, and DNR) and five (Pred, VC…

Source: Cancer MedicineCategory: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

Conclusion: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

Source: In VivoCategory: Research Authors: Tags: Experimental Studies Source Type: research

We present a 2-year-old boy with bilateral foot pain that worsened over 6 months. X-rays of the feet showed no obvious abnormalities. Magnetic resonance imaging revealed abnormal bone marrow consistent with an infiltrative process. The patient was found to have precursor B-cell acute lymphoblastic leukemia. Cases such as these highlight the possible future use of magnetic resonance imaging in the early diagnostic workup for bone and muscle pain.
PMID: 31384202 [PubMed]

Childhood leukemia, the commonest childhood cancer, is mainly consisted of acute lymphoblastic leukemia(ALL) and acute myeloid leukemia(AML). Though great progresses have been made in the survival rates of childhood leukemia, the long-term health problems of childhood leukemia survivors are remained remarkable. And the deep links between risk factors and childhood leukemia are in great need to be elucidated. What can be done to improve the prevention and the prognosis of childhood leukemia is an essential issue. Gut microbiota, referred to as one of the largest symbiotic microorganisms that accommodated in the gastrointest…

Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation of lymphoid precursors with arrested maturation. Although chemotherapeutic approaches have been achieving successful remission for the majority of cases of childhood ALL, development of resistance to chemotherapy has been observed. Thus, new therapeutic approaches are required to improve patients prognosis. Therefore, we investigated the anticancer potential of curcumin in ALL. We tested a panel of B-precursor ALL (B-Pre-ALL) cell lines with various translocations after treatment with different doses of curcumin. …


The central nervous system (CNS) may be considered as a sanctuary site, protected from systemic chemotherapy by the meninges, the cerebrospinal fluid (CSF) and the blood-brain barrier (BBB). Consequently, parenchymal and CSF exposure of most antineoplastic agents following intravenous (IV) administration is lower than systemic exposure. In this review, we describe the different strategies developed to improve delivery of antineoplastic agents into the brain in primary and metastatic CNS tumors. We observed that several methods, such as BBB disruption (BBBD), intra-arterial (IA) and intracavitary chemo…

Source: CancersCategory: Cancer & Oncology Authors: Tags: Review Source Type: research

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