Compatibility With Real-World Samples Collected from Outdoor and Subway Surfaces

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Source: U.S. Environmental Protection Agency, Office of Research and Development, National Homeland Security Research Center (NHSRC). Published: 6/2019.
This 255-page report provides information about an effort that sought to assess the impact of potential real-world interferents present in sponge-stick and vacuum cassettes samples on current culture and molecular analysis methods for the detection of bacillus anthracis spores. Having an assessment of the impact, if any, will help EPA understand limitations of the current methods for contaminant spread and extent mapping, and identify possible opportunities or needs for method improvement. Following a biological contamination incident, the spatial extent of the contamination should be determined using established sampling and analytical methods.
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In this report, we extracted the essential oil from the aerial parts of the A. tenuifolia (collected from Khoy), at various developmental stages (i.e. vegetative, flowering and fruiting), characterize them and study their antibacterial activities. Of 46, 51 and 38 components found in the vegetative, flowering, and fruiting stages, respectively, 35 were present in all three stages, including oxygenated terpenes such as carvacrol (30.85-34.11), germacrene-C (17.87-16.21), spathulenol (8.96-7.26), β-sesquiphellandrene 4.25-4.11), t-muurolol (3.25-2.27) and α-cadinol (3.29-2.01). We witnessed that the composition of…

Source: Chemistry and BiodiversityCategory: Biochemistry Authors: Tags: Chem Biodivers Source Type: research

Abstract
Burkholderia pseudomallei (B. pseudomallei), the etiological agent of melioidosis, is a Gram-negative bacterium with additional concern as a biothreat pathogen. The mortality rate from B. pseudomallei varies depending on the type of infection and extent of available health care, but in the case of septicemia left untreated it can range from 50 – 90%. Current therapy for melioidosis is biphasic, consisting of parenteral acute-phase treatment for two weeks or longer, followed by oral eradication-phase treatment lasting several months. An effective oral therapeutic for outpatient treatment of acute-phase mel…

Source: Antimicrobial Agents and ChemotherapyCategory: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research

ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b11650

Source: ACS Applied Materials and InterfacesCategory: Materials Science Authors: Source Type: research

A gas explosion has sparked a fire at a Russian bioweapons facility which stores viruses including Ebola, smallpox and Anthrax.
The blast occurred on Monday after a gas cylinder exploded during scheduled repair work on the fifth floor of the six-story Russian State Centre for Research on Virology and Biotechnology, commonly known as Vector, the facility said in a statement.
No biological material was held in the sanitary inspection room where the explosion occurred, and no structural damage was caused to the concrete laboratory building, the center added.
One worker was taken to hospital and is being treated in intensive c…

Source: TIME: ScienceCategory: Science Authors: Tags: Uncategorized onetime russia smallpox Source Type: news

PMID: 31525744 [PubMed – in process]

Source: Annals of Internal MedicineCategory: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research

Lexington diagnostics maker T2 Biosystems is pairing up with the U.S. government to develop tests that could identify biological threats like anthrax — a deal that could alleviate some of the struggling device company’s financial concerns.

Publication date: Available online 4 September 2019Source: Progress in Natural Science: Materials InternationalAuthor(s): A.Z. Mahmoud, A.A.A. Darwish, Saleem I. QashouAbstractThe effect of film thickness on the structural and optical properties of bisbenzimidazo [2,1-a:2′,1′-a′] anthrax [2,1,9-def:6,5,10-d′e′f′] diisoquinoline-10,21-dione (BI-diisoQ) films was carried out. The morphology of BI-diisoQ film showed a definite shape of a nanorod with a length of around 5 μm and a diameter of approximately 20 nm. Also, X-ray diffraction patterns demonstrated that BI-diisoQ thin films …

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03342

Source: Analytical ChemistryCategory: Chemistry Authors: Source Type: research

Anthrax is a zoonotic disease caused by the gram-positive bacterium Bacillus anthracis. The most anthrax-endemic regions of Russia are Siberia and North Caucasus. Previously, genotyping of Russian B.anthracis iso…

Source: BMC GenomicsCategory: Genetics & Stem Cells Authors: Tags: Research article Source Type: research

Source: U.S. Environmental Protection Agency, Office of Research and Development, National Homeland Security Research Center (NHSRC). Published: 9/2019.
This 43-page report summarizes the results of biological decontamination experiments performed at the Water Security Test Bed (WSTB). The experiments focused on removing and remediating Bacillus globigii spores adhered to the inner surface of the eight-inch water pipe. Bacillus globigii spores are a non-pathogenic surrogate for Bacillus anthracis, which is the causative agent of anthrax. First responders and decision-makers managing a water contamination event can use dat…

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