Greater prevalence of anal cancer precursors for women living with HIV than prior reports


(Boston Medical Center) The prevalence of anal high-grade squamous intraepithelial lesions (HSIL), which precede anal cancer, is much higher in women living with HIV than previously reported, a multi-site, national study involving hundreds of patients has found.

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To investigate the prognostic significance of positron emission tomography (PET) parameters from F-18 fluorodeoxyglucose (FDG) PET scans performed pre- and post- chemo-radiotherapy (CRT) for squamous cell carc…

Source: Radiation OncologyCategory: Cancer & Oncology Authors: Tags: Research Source Type: research

AbstractStandardized terminology is critical to providing consistent reports to referring clinicians. This lexicon aims to provide a reference for terminology frequently used in rectal cancer and reflects the consensus of the Society of Abdominal Radiology Disease Focused Panel in Rectal cancer. This lexicon divided the terms into the following categories: primary tumor staging, nodal staging, treatment response, anal canal anatomy, general anatomy, and treatments.

Doublet chemotherapies are the mainstay in the management of metastatic anal cancer. Immunotherapy has been incorporated into guidelines in a refractory setting. Treatment options remain limited with tumor progression beyond immunotherapy. Modified  docetaxel, cisplatin, and fluorouracil (mDCF) chemotherapy, after progression postimmunotherapy, has shown a near‐complete response in our patient with metastatic anal cancer. This likely is secondary to the sequence of immunotherapy followed by chemotherapy that is yielding greater than histo rical responses. AbstractDoublet chemotherapies are the mainstay in …

Source: Clinical Case ReportsCategory: General Medicine Authors: Tags: CASE REPORT Source Type: research

CONCLUSIONS: Malignant tumorswere still the main cause of death in one’s life time, giving rise to LDP. LDP caused by malignant tumours has twodivisions. First, traditional upper digestive system cancers related to long-term chronic infection, such as esophagealcancer, gastric cancer, and liver cancer, which has shown a significant downward trend. Second, lung and colorectalcancers related to the environmental factors and lifestyle, which are on the rise.
PMID: 31350960 [PubMed – in process]

ConclusionsInfrared coagulation is a safe and effective method for ablation of high-grade anal dysplasia that could help prevent anal cancer. Continued surveillance is recommended due to the risk of recurrence.

Authors call for new screening strategies for anal cancer prevention in women living with HIV

Source: The Doctors Lounge – OncologyCategory: Cancer & Oncology Tags: Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Oncology, Pathology, Surgery, Journal, Source Type: news

In this study, we used electronic health record data from a single urban cancer center to identify patients from 2004-2018 with anal cancer who have also had a pre-initial treatment CEA measurement. We identified 40 patients who met our eligibility criteria. Of those, 11 (27.5%) had an elevated pretreatment CEA. Elevated CEA was not associated with any of the clinical or demographic covariates; however, three out of five patients with a recurrence had an elevated CEA.
PMID: 31319725 [PubMed – as supplied by publisher]

Source: Cancer InvestigationCategory: Cancer & Oncology Tags: Cancer Invest Source Type: research

CONCLUSIONS:
In our population-based cohort of HIV-infected subjects with long-term follow-up, the risk of progression from anal intraepithelial neoplasia III to anal squamous cell carcinoma was higher than reported in other studies and was not associated with the receipt of anal intraepithelial neoplasia III treatment. See Video Abstract at http://links.lww.com/DCR/A933.

ConclusionsPractitioners who provide care for PLWH are proactive in screening to help prevent and control anal cancer, a rare and slow-growing disease. Continuing to regularly surveil high-risk populations, particularly PLWH previously diagnosed with high-grade lesions, is critical to prevent and control anal cancer.

Abstract
Purpose: To determine if anal cancer patients with HPV positive disease have different overall survival (OS) compared to those with HPV negative disease, and to elucidate differences in the association between radiation dose and OS. Patients and methods: We utilized the National Cancer Database (NCDB) registry to identify a cohort of non-metastatic anal cancer patients treated with curative intent between 2008 and 2014. Propensity score matching was used to account for potential selection bias between patients with HPV positive and negative disease. Multivariable Cox regression was used to determine the a…

Source: Acta OncologicaCategory: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research



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