A new suggests that the gene expression signature 4-GES, which consists of four genes (SOCS2, IL2RA, NPDC1, PHGDH), may be an independent prognostic factor in acute myeloid leukemia (AML). Writing in Scientific Reports, researchers report 4-GES is a highly significant independent prognostic parameter throughout several independent AML cohorts and it has a major advantage over previously published signatures because it is composed of only four genes.
AbstractPatients with hematological malignancies are severely immunocompromised and are at high risk of invasive fungal infection (IFI), particularly those undergoing remission-induction chemotherapy for acute myeloid leukemia (AML). IFIs are a major cause of morbidity and mortality in such patients. We planned to study the incidence of IFI in patients with AML undergoing intensive chemotherapy and receiving antifungal prophylaxis. We retrospectively reviewed consecutive 46 patients with non-M3 AML, who received induction chemotherapy and systemic antifungal prophylaxis. None of the patients had IFI at the time of initiati…
Publication date: Available online 2 August 2019Source: Blood Cells, Molecules, and DiseasesAuthor(s): Nan Zhang, Ying Chen, Yan Shen, Shifeng Lou, Jianchuan DengAbstractAcute myeloid leukemia (AML) is a common form of hematological malignancies, the discovery of non-coding RNA (ncRNA) plays an important role in diverse biological processes including hematopoietic differentiation and proliferation. However, the interaction mechanism of key RNAs and their regulatory network in childhood AML are still to be elucidated. RNA profiles were downloaded from the Therapeutically Applicable Research to Generate Effective Treatment (…
Publication date: Available online 1 August 2019Source: Stem Cell ReportsAuthor(s): Juan Bautista Menendez-Gonzalez, Milica Vukovic, Ali Abdelfattah, Lubaid Saleh, Alhomidi Almotiri, Leigh-anne Thomas, Aloña Agirre-Lizaso, Aleksandra Azevedo, Ana Catarina Menezes, Giusy Tornillo, Sarah Edkins, Kay Kong, Peter Giles, Fernando Anjos-Afonso, Alex Tonks, Ashleigh S. Boyd, Kamil R. Kranc, Neil P. RodriguesSummarySubversion of transcription factor (TF) activity in hematopoietic stem/progenitor cells (HSPCs) leads to the development of therapy-resistant leukemic stem cells (LSCs) that drive fulminant acute myeloid leukemia…
Publication date: Available online 1 August 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Evandro D. Bezerra, Megan Othus, Carole Shawn, Mary-Elizabeth Percival, Kelda Gardner, Roland B. Walter, Pamela S. Becker, Paul C. Hendrie, Elihu H. Estey
Growing evidence has demonstrated that epigenetic dysregulation is a common pathological feature in human cancer cells. Global alterations in the epigenetic landscape are prevalent in malignant cells across different solid tumours including, prostate cancer, non-small-cell lung cancer, renal cell carcinoma, and in haemopoietic malignancy. In particular, DNA hypomethylation and histone hypoacetylation have been observed in acute myeloid leukaemia (AML) patient blasts, with histone methylation being an emerging area of study.
Histone 3 lysine 9 trimethylation (H3K9me3) is a post-translational modification known to be invol…
We examined the prognostic significance of UPDs and frequency of LOH in CN-AML patients.
EXPERIMENTAL DESIGN: We examined the frequency and prognostic significance of UPDs in a set of 425 adult de novo CN-AML patients who were previously sequenced for 81 genes typically mutated in cancer. Associations of UPDs with outcome were analyzed in the 315 CN-AML patients younger than 60 years.
RESULTS: We detected 127 UPDs in 109 patients. Most UPDs were large and typically encompassed all or most of the affected chromosome arm. The most common UPDs occurred on chromosome arms 13q (7.5% of patients), 6p (2.8%) and 11p (2….
Acute myeloid leukemia (AML) is characterized by the accumulation of immature white blood cell precursors in the bone marrow and peripheral circulation. In essence, leukemic cells fail to differentiate and are stalled at a particular step of hematopoietic maturation and are unable to complete their development into functional blood cells with a finite life cycle. They are thus said to possess a “differentiation block.” Pharmacological override of this block is one attractive avenue of therapy, termed “differentiation therapy.” The most successful example of this therapeutic strategy is…
Authors: Liu Z, Hua Y, Liu C, Cheng S
PMID: 31359748 [PubMed – as supplied by publisher]
PMID: 31371420 [PubMed – as supplied by publisher]