Discovery of distinct lung cancer pathways may lead to more targeted treatments


JACKSONVILLE, Fla. — Known for its poor prognosis, lung adenocarcinoma is the most common type of lung cancer, responsible for about 4 of 10 diagnoses, according to the National Cancer Institute. Researchers on Mayo Clinic’s Florida campus can now distinguish between two pathways where this deadly cancer can develop. They say their discovery could help future patients. […]

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ConclusionThis study provides a prefatory evidence on T. itama honey’s significant anticancer activity against human lung cancer cell lines.

Conclusion: This study suggests that CNAs profiling may be a potential prognostic classifier in resected LAUD patients. Amplifications of 12p12.1 and KDM5A might be prognostic biomarkers for LUAD, and amplification of ERBB2 and deletion of 4q34.3 predicted early relapse after adjuvant chemotherapy. These novel findings may provide implication for better implementation of precision therapy for lung cancer patients.

ROS1 rearrangements are validated drivers in lung cancer, which have been identified in a small subset (1 –2%) of patients with non-small cell lung cancer (NSCLC). To date, 18 fusion genes of ROS1 have been identi…

Source: BMC CancerCategory: Cancer & Oncology Authors: Tags: Case report Source Type: research

Malignant pleural effusions (MPEs) can be observed in patients with various types of neoplasm, especially lung adenocarcinoma, since it grows in the periphery of the lung and easily invades the pleural cavity[1,2].Although DNA from tissue can better reflect the genomic mutation in various cancers, the inadequate amount of tumor specimens and the risky invasive procedure have limited the availability of tumor tissue for molecular analysis [3,4].Instead, MPE sample may be an attractive alternative to lung biopsy for genotyping, as the collecting method is less invasive, and mutations of EGFR can also be detected in pleural e…

Source: Lung CancerCategory: Cancer & Oncology Authors: Source Type: research

Conclusions: To the best of our knowledge, this is the first hot spot profiling study on patients from this area. The frequencies of mutated genes presented in our study showed similarity to other reported outcomes. At least one mutation was detected in our cohort of LUAD.
PMID: 31372275 [PubMed]

In this study we show that whole-body irradiation with H→He→Si increases the incidence of premalignant lesions and systemic oxidative stress in mice 100 days post-irradiation more than (Si→He→H) and H only irradiation. Additionally, we observed an increase in adenomas with atypia and adenocarcinomas in H→He→Si irradiated mice but not in (Si→He→H) or H (30 cGy) only irradiated mice. When we used the H→He→Si irradiation sequence but skipped a day before exposing the mice to Si, we did not observe the increased incidence of cancer initiation and progression. We also found that…

Conclusions: The observed differences in characteristics between never-smokers and smokers, and the higher survival in never-smokers compared to smokers from this large population-based study provide further evidence that lung cancer in never-smokers is clinically different to tobacco-associated lung cancer. The findings from this study emphasise the need for an improved understanding of genetics, pathogenesis, mechanisms and progression of non-tobacco associated lung cancer that may help prevent lung cancer or identify individually targeted treatments.
PMID: 31373239 [PubMed – as supplied by publisher]

Source: Acta OncologicaCategory: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research

This study was initiated to explore their protein expression patterns and prognostic value in patients with operable lung cancer disease.
The protein abundance (in the following text also named protein expression) of ATRX and DAXX were analyzed by immunohistochemistry in 194 samples of squamous cell lung carcinoma (SQCLC), 111 samples of pulmonary adenocarcinoma (AC) and 40 samples of small cell lung cancer (SCLC). The protein levels of ATRX and DAXX were correlated with clinicopathological characteristics and patient outcome.
ATRX showed strong protein expression in 16.2% of AC, 11.9% of SQCLC, and 42.5% of SCLC. DAXX w…

Source: MedicineCategory: Internal Medicine Tags: Research Article: Observational Study Source Type: research

ConclusionsPET/CT, as a non-invasive method, can be preferred as the first choice in the detection of primary tumor in patients with BMUO.ResumenObjetivoEste trabajo analiza el papel de la PET/TC con 18F-FDG en la detección del tumor primario en pacientes con metástasis óseas de origen desconocido (MOOD).Material y MétodosEste estudio retrospectivo consideró al análisis histopatológico o el seguimiento clínico como datos de referencia en el diagnóstico de tumores primarios y estos resultados fueron comparados con los resultados de la PET/TC.ResultadosSe incluye…

AbstractBackgroundThe cell adhesion molecule close homologue ofL1 (CHL1) is a potential tumour suppressor and was recently detected in non-small cell lung cancer (NSCLC) specimens. The expression pattern, prognostic, and functional role of CHL1 in NSCLCs is unknown.MethodsWe evaluated the protein expression of CHL1 by immunohistochemistry in 2161 NSCLC patients based on a tissue microarray. The results were correlated with clinical, histopathological, and patient survival data (Chi square test,t test, and log-rank test, respectively). A multivariate analysis (Cox regression) was performed to validate its impact on patients…

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