Overweight, Obesity May Up Early Mortality Risk in Pediatric ALL


MONDAY, Aug. 5, 2019 — For Mexican children with acute lymphoblastic leukemia (ALL), overweight and obesity are predictors of early mortality, according to a study published online July 18 in BMC Cancer.
Juan Carlos N úñez-Enríquez, M.D., from…

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Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood…

Source: BMC CancerCategory: Cancer & Oncology Authors: Tags: Research article Source Type: research

BackgroundThe outcomes of older adults with acute lymphoblastic leukemia (ALL) remain poor when compared to younger ALL patients [PMID 19897583, 28419558, 22409379, 10653870]. Asparaginase (Asp) induces death of human lymphoblasts, and effective asparagine depletion is associated with improved outcomes in ALL. PEG-Asparaginase (PEG-Asp), which has a longer half-life than Asp, is a key component of the intensive chemotherapeutic regimens utilized for treatment of pediatric and younger adult ALL [PMID 29450465]. Frequently, older patients with Ph-negative ALL are not offered PEG-Asp containing pediatric chemotherapy regimen …

Source: BloodCategory: Hematology Authors: Tags: 612. Acute Lymphoblastic Leukemia: Clinical Studies Source Type: research

Something as simple as a change in diet can potentially help to increase the cancer survival rate of obese children with acute lymphoblastic leukemia, the most common childhood cancer, according to a new study by UCLA scientists.The research team, led by Dr. Steven Mittelman, chief of pediatric endocrinology at  UCLA Mattel Children ’s Hospital and member of the  UCLA Jonsson Comprehensive Cancer Center, administered the chemotherapy drug vincristine to obese and non-obese mice with leukemia. Researchers discovered that if they switched the obese mice from a high-fat to a low-fat diet immediately befor…

AbstractBackgroundIt is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL.MethodsDiet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL cells. Some DIO mice were switched to the low-fat control diet. Survival from ALL was assessed without or …

Genes, Chromosomes and Cancer,Volume 0, Issue ja, -Not available-.

Source: Genes, Chromosomes and CancerCategory: Cancer & Oncology Authors: Source Type: research

(University of California – Los Angeles Health Sciences) Something as simple as a change in diet can potentially help to increase the cancer survival rate of obese children with acute lymphoblastic leukemia, the most common childhood cancer, according to a new study by UCLA scientists.

Pediatric Blood&Cancer, EarlyView.

Source: Pediatric Blood and CancerCategory: Cancer & Oncology Authors: Source Type: research

AbstractBackgroundChildren with acute lymphoblastic leukemia (ALL) have an increased risk of obesity and short stature. To the authors ’ knowledge, data regarding patients treated on contemporary protocols without cranial irradiation are limited.MethodsChanges inzscores for body mass index (BMI), height, and weight from the time of diagnosis to 5 years off therapy were evaluated using multivariable analysis in 372 children with ALL who were aged 2 to 18 years at the time of diagnosis and were enrolled on the St. Jude Children ’s Research Hospital Total XV protocol from 2000 through 2007.ResultsThe percentage of…

Source: CancerCategory: Cancer & Oncology Authors: Tags: Original Article Source Type: research

Authors: Corella Aznar EG, Ayerza Casas A, Carboné Bañeres A, Calvo Escribano MÁC, Labarta Aizpún JI, Samper Villagrasa P
BACKGROUND: Survival of childhood acute lymphoblastic leukaemia involves an increasing risk of long-term morbidities. Due to the impact of cancer treatment and comorbidities, AL survivors may experience a decrease in their health-related quality of life.
OBJECTIVE: We aimed to describe the long-term comorbidities, related quality of life and their development predictors in these survivors.
METHODS: cross-sectional study of 54 survivors aged ≥18 and…

Source: Medicina ClinicaCategory: General Medicine Tags: Med Clin (Barc) Source Type: research

Authors: Simioni C, Zauli G, Martelli AM, Vitale M, Ultimo S, Milani D, Neri LM
A decreased physical fitness has been reported in patients and survivors of acute lymphoblastic leukemia (ALL). This is influenced by the negative effects of the disease and by the treatments of childhood cancer. In the past, children were advised to recover in bed, and to take as much relax as possible. Nowadays, it is considered that too much immobility may result in a further decrease of physical fitness and functioning. Exercise training for ALL children has frequently been reported to improve physical fitness and the well-…

Source: OncotargetCategory: Cancer & Oncology Tags: Oncotarget Source Type: research

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