Azelastine Hydrochloride & Fluticasone Propionate (Dymista) for Allergy

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What is azelastine hydrochloride and fluticasone propionate, and how does it work (mechanism of action)?

Dymista is a prescription nasal spray used to treat
symptoms of seasonal allergic rhinitis (inflammation of the lining of the nose)
such as runny nose, stuffy nose, itching, and sneezing. Dymista contains two
medicines, azelastine hydrochloride and fluticasone propionate, which are also
available individually as nasal sprays. In Dymista, azelastine hydrochloride an
antihistamine, and fluticasone propionate, a corticosteroid work in different
yet complementary ways.

Azelastine hydrochloride blocks the release and actions of histamine, a
chemical responsible for causing many of the symptoms of allergy. Fluticasone
propionate is a corticosteroid that reduces inflammation and the body’s immune
response. When used together, azelastine hydrochloride and fluticasone
propionate provide better relief of symptoms than either medicine alone. In
clinical trials, Dymista was superior to azelastine nasal spray, fluticasone
nasal spray, and placebo in providing symptom relief. Dymista was approved by
the FDA in May, 2012.

What brand names are available for azelastine hydrochloride and fluticasone propionat?

Dymista

Is azelastine hydrochloride and fluticasone propionate available as a generic drug?

No

Do I need a prescription for azelastine hydrochloride and fluticasone propionate?

Yes

What are the side effects of azelastine hydrochloride and fluticasone propionate?

The most common side effects of Dymista are changes in taste,
nosebleeds, and headache.

Dymista may cause some more serious side effects including:

What is the dosage for azelastine hydrochloride and fluticasone propionate?

The recommended dose to treat seasonal allergic rhinitis is 1 spray
in each nostril twice daily.



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Which drugs or supplements interact with azelastine hydrochloride and fluticasone propionate?

Taking Dymista with alcohol or CNS depressants may cause additive drowsiness
or sleepiness.

Fluticasone propionate is metabolized or broken down by the CYP3A4 enzymes in
the liver. Strong inhibitors of CYP3A4 enzymes such as ritonavir (Norvir),
ketoconazole (Extina, Nizoral), fluconazole (Diflucan), and itraconazole (Onmel,
Sporanox) may increase its blood levels and increase the risk of side effects.
Dymista should not be used with ritonavir or medicines containing ritonavir.

Is azelastine hydrochloride and fluticasone propionate safe to take if I’m pregnant or breastfeeding?

It is not known if Dymista is excreted in breast milk.
Because many drugs are excreted into breast milk and can potentially harm the
nursing infant, Dymista should be used cautiously during nursing.

What else should I know about azelastine hydrochloride and fluticasone propionate?

What preparations of azelastine hydrochloride and fluticasone propionat are available?

Nasal spray: 137 mcg of azelastine hydrochloride and 50 mcg of
fluticasone propionate (137 mcg/50 mcg) in each metered spray. Each canister
delivers 120 metered sprays after priming.

How should I keep azelastine hydrochloride and fluticasone propionate stored?

Dymista nasal spray should be stored upright at room temperature,
between 20 C to 25 C (68 F to 77 F).

Medically Reviewed on 8/5/2019

References

REFERENCE:

FDA Prescribing Information





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