Interferon-gamma replacement as salvage therapy in chronic pulmonary aspergillosis: impact on bacterial exacerbations and hospital admissions

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This study aims to investigate the effects of cinnamaldehyde on 1,3-β-D-glucans in the pulmonary Aspergillus fumigatus cell wall to provide a basis for developing novel antifungal drugs.MethodsImmunosuppressed ICR mice were intranasally inoculated with 50 µL of A. fumigatus suspension (1 × 107 CFU/mL) and then separated into two groups, for the experimental group cinnamaldehyde was orally administered at 240 mg/kg/d consecutively for 14 d. While for the control group, voriconazole was used to treat the fungus infection. Pulmonary tissues were then extracted for 1,3-β-D-glucans assay and electron m…

Publication date: Available online 12 September 2019Source: Journal de Mycologie MédicaleAuthor(s): Dhoha Ghorbel, Inès Hadrich, Sourour Neji, Houaida Trabelsi, Hatem Belaaj, Hayet Sellami, Fatma Cheikhrouhou, Fattouma Makni, Ali AyadiAbstractAspergillus flavus is the second leading cause of invasive and non-invasive aspergillosis. Secretion of hydrolytic enzymes is considered as a virulence factor in this species. Our work aimed to study in vitro production of some virulence factors, to evaluate the biofilm production against human and avian A. flavus isolates and to investigate the antifungal susceptibility…



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