Synthetic Opioid Uses, Side Effects & Withdrawal

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What is methadone liquid-oral, and how does it work (mechanism of action)?

Methadone is a strong,
synthetic (man-made) narcotic that acts on the central
nervous system (brain) in a manner similar to other narcotics. It is used in
the management of narcotic addiction and for pain control. Methadone was
first approved by the Food and Drug Administration on August 13, 1947.

What brand names are available for methadone liquid-oral?

Dolophine; Methadone HCl Intensol; Methadose; Methadose Sugar-Free

Is methadone liquid-oral available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for methadone liquid-oral?

Yes

What are the uses for methadone liquid-oral?

Methadone is used for the treatment of moderate to
severe pain when non-narcotic pain medications have failed. The extended release
methadone tablets should be reserved for severe and continuous pain that
requires long-term pain treatment after a failed trial of non-narcotic
medications and should be avoided in individuals requiring as-needed pain
control.

What are the side effects of methadone liquid-oral?

Methadone is very addicting and causes
significant sedation and respiratory depression. Methadone side effects include:

These tend to occur during the
first few days as the body adjusts to the medication. Methadone also may cause:

Some of these
side effects may go away with continued use.

What is the dosage for methadone liquid-oral?

  • The initial dose of oral methadone in patients who
    require continuous pain control throughout the day can range from 2.5 to 10 mg
    given every 8 to 12 hours.
  • Those who are seriously ill may need to be started at
    an oral dose of 10 to 40 mg given every 6 to 12 hours.
  • The initial total daily
    dose for detoxification usually is higher, and this can range from 20 to 120 mg
    daily.
  • The usual dose for methadone solution for injection when treating
    moderate to severe pain in patients who require continuous pain control is 2.5
    to 10 mg given as intravenous (I.V.), subcutaneous (SubQ) or intramuscular
    (I.M.) injection every 8-12 hours.
  • The conversion ratio from oral methadone to
    methadone given as an injection (I.V., SubQ) or I.M.) is 2:1. The total daily
    amount of methadone that a person is prescribed is not fixed, and it will depend
    on many factors including the severity of the pain, prior use of methadone,
    medications that are being taken concomitantly, the response to treatment and
    other factors that may be specific to a person.
  • Therefore, each person has to be
    monitored carefully while receiving methadone. When stopping therapy, the dose
    of methadone should be gradually reduced in order to avoid withdrawal symptoms.

Which drugs or supplements interact with methadone liquid-oral?



QUESTION


About how much does an adult human brain weigh?
See Answer

Is methadone liquid-oral safe to take if I’m pregnant or breastfeeding?

Safety during
pregnancy has not
been established. Methadone has been shown to cross the placenta, and it is
found in cord blood, amniotic fluid and in the newborn urine. Children born to
mothers who were taking methadone for a prolonged period may exhibit respiratory
depression or withdrawal symptoms. Methadone enters breast milk, and this can
cause sedation and respiratory depression in the breast feeding infant. The
benefit to the mother of taking methadone while breast feeding should be weighed
against the risks to the infant.

What else should I know about methadone liquid-oral?

What preparations of methadone liquid-oral are available?
  • Oral concentrate: 10 mg/mL;
  • Oral solution: 5
    and 10 mg per teaspoon;
  • Oral tablet: 5 mg and 10 mg;
  • Soluble tablet, 40mg;
  • Solution for Injection 5 and 10 mg per teaspoon: 10 mg/mL.
How should I keep methadone liquid-oral stored?

Oral methadone and injection should be stored at
room temperature between 15 C and 30 C (59 F and 86 F). Methadone
injection also should be protected from light.

Medically Reviewed on 8/19/2019

References

REFERENCE:

FDA Prescribing Information.





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