Monday's pick of the day

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The first day of BES 2014 kicks off with a host of varied, topical symposia, clinical management workshops, and an applied physiology workshop. Look out for our first education workshop at 15.45, room 3B Teaching and learning in endocrinology. Make sure you catch Peter Taylor’s talk at 13.45, room 1A on the link between low thyroid hormone levels and a genetic variant, and the development of low IQ. The work is covered today in news stories in the Telegraph, BBC and Mail online. The abstract is the Clinical Endocrinology Trust top-scoring clinical abstract. We are grateful to our industry supporters who have enabled us to bring you four satellite symposia. The first two: Vitamin D – the Dark Truth, sponsored by Internis takes place at 12.45, room 1C and Cushing’s syndrome and adrenocortical carcinoma management: are we making progress?, sponsored by HRA Pharma at the same time in room 1B. At 17.25 in room 1A, come and support our Young Endocrinologists’ Prize Lectures. Following the Welcome Reception, our YE’s are set for an evening of fun and trivia at the Young Endocrinologists’ social evening and quiz from 20.15. Tickets are free, but must be pre-booked. Check availability at the registration desk.

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This study is a post-hoc analysis of steroid hormones before and after administration of pharmacological doses of soy isoflavones in a large cohort of men and women from two independent studies. Isoflavones are reported to inhibit mineralo- and glucocorticoid hormone production as well as reproductive steroids in vivo and in vitro. We focused on cytochrome P450 17α-hydroxylase (CYP17A1) which catalyses the production of dehydroepiandrosterone (DHEA), in the androgen biosynthesis pathway to elucidate effects on sex steroids in vitro. Design and Setting: Effects of soy isoflavones on steroid levels in two studies comp…

Authors: Wang K, Liu F, Wu C, Liu Y, Qi L, Yang X, Zheng H, Ma A, Wu J, Yan F, Hou X, Chen L, Dong M, Hou W Abstract Cushing’s syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing’s syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing’s syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Endocrinological examinations indicated CCS with periodic and intermittent increases in cortisol. Enhanced computed tomography (CT) revealed space occupying …

Source: Endocrine Journal – December 22, 2018Category: Endocrinology Tags: Endocr J Source Type: research

ConclusionsApproximately 60% of patients with adrenocortical carcinoma present with symptoms and signs of hormonal secretion. Our cases ’ adrenocortical carcinomas were not functional. Hormone secretion is not a discriminating feature between benign and malignant adrenocortical masses. The silent clinical nature of nonfunctioning adrenocortical carcinoma results in late diagnosis, while the majority of patients present with locall y advanced and/or metastatic disease.Adrenocortical carcinoma is a rare endocrine tumor with a poor prognosis that can be diagnostically challenging and demands high clinical suspicion. The…

We report an interesting case of hepatic ACC in a young woman with clinical signs of virilization.A-21-year old Sundanese woman visited our endocrine clinic with progressive hirsutism over the face, body, and extremities starting 14 years previously. She had irregular, heavy periods when she was 7 years old. She also experienced pubertal development of her breasts. However, both menstrual cycle and breast development ceased when she was 8 years old. She noticed voice deepening and alopecia. Physical examination showed male-type alopecia and intense hirsutism. Tanner stage was 3 for breast tissue and 5 for pubic hair. There…

Source: Acta medica Indonesiana – October 21, 2018Category: Internal Medicine Tags: Acta Med Indones Source Type: research

In conclusion, sex, BMI and age are associated with the incidence and survival rates for cancers. These results could be used to supplement precision and personalized medicine. PMID: 29956810 [PubMed – as supplied by publisher]

Source: Oncology Reports – July 1, 2018Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Abstract Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid ha…

Source: Presse Medicale – June 13, 2018Category: General Medicine Authors: Al-Salameh A, Baudry C, Cohen R Tags: Presse Med Source Type: research

We present the challenges and the opportunities of using immune checkpoint inhibitors against these endocrine malignancies, highlighting the breakthroughs and pitfalls that have recently emerged.

Source: Endocrine-Related Cancer – November 2, 2017Category: Endocrinology Authors: Cunha, L. L., Marcello, M. A., Rocha-Santos, V., Ward, L. S. Tags: Thematic Review Source Type: research

Publication date: Available online 24 August 2016 Source:Journal of Comparative Pathology Author(s): J.A. Ramos-Vara, C.B. Frank, D. DuSold, M.A. Miller Expression of thyroid transcription factor (TTF)-1 corroborates a thyroid origin of neoplasms. Thyroglobulin and calcitonin immunohistochemistry (IHC) can distinguish between a follicular and C-cell origin of thyroid tumours, respectively. Pax8 (expressed by normal canine thyroid follicular cells) and napsin A (expressed mainly by C-cells) labelling was compared with labelling for TTF-1, thyroglobulin and calcitonin in 114 canine proliferative thyroid lesions. All 81 foll…

CONCLUSIONS: There was considerable heterogeneity in the TP53 mutations and tumor spectrum in Korean patients with LFS. Our results suggest shared and different LFS characteristics between Caucasian and Korean patients. This is the first report on the mutation spectrum and clinical characteristics from the largest series of Korean LFS patients. PMID: 27374712 [PubMed – in process]

We present the case of a previously unreported bilateral adrenal hemorrhage occurring in a 59-year-old Caucasian male who was admitted to our surgical division with the diagnosis of a right retroperitoneal spontaneous hemorrhage. Imaging revealed a 10-cm ruptured right adrenal mass with no other abdominal lesions, endocrine screening results were normal, and a right adrenalectomy was performed. Pathology revealed a ruptured ACC. The postoperative period was uneventful and the patient was discharged. While recovering, 3 weeks after the operation, the patient showed the same symptoms on the contralateral side. Imaging o…



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