Clusters of living brain cells are teaching scientists about diseases like autism. With a new finding, some experts wonder if these organoids may become too much like the real thing.
Targeting CSC in a Most Aggressive Subtype of Breast Cancer TNBC.
Adv Exp Med Biol. 2019;1152:311-334
Authors: Bao B, Prasad AS
Triple negative breast cancer (TNBC) is a more aggressive subtype of breast cancer and is characteristic of the absence of the expressions of estrogen receptor, progesterone receptor, and human epithelial growth factor receptor 2 in breast tumor tissues. This subtype of breast cancer has the poorest prognosis, compared to other subtypes of breast cancer. TNBC is heterogeneous by showing several different histo-pathological and molecular subtypes with different pr…
Authors: Coughlin SS
Epidemiologic studies have contributed importantly to current knowledge of environmental and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of human suffering and premature mortality among women. In the United States, breast cancer accounts for more cancer deaths in women than any site other than lung cancer. A variety of risk factors for breast cancer have been well-established by epidemiologic studies including race, ethnicity, family history of cancer, and genetic traits, as well as modifiable exposures such as increased alcohol consumption, p…
Authors: Forcelli PA
AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder Yennawar M, White RS, Jensen FE. J Neurosci. 2019;39(24):4814-4828. Pathogenic mutations in cyclin-dependent kinase-like 5 (CDKL5) result in CDKL5 deficiency disorder (CDD), a rare disease marked by early-life seizures, autistic behaviors, and intellectual disability. Although mouse models of CDD exhibit dendritic instability and alterations in synaptic scaffolding proteins, studies of glutamate receptor levels and function are limited. Here, we used a novel mouse model of CDD, the C…
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Ultrasound misses signs of early Zika infection
The Zika virus (ZIKV) became a major worldwide public concern in 2015 due to the congenital syndrome which presents the highest risk during the first trimester of pregnancy and includes microcephaly and eye malformations. Several cellular, genetic and molecular studies have shown alterations in metabolic pathways, endoplasmic reticulum (ER) stress, immunity and dysregulation of RNA and energy metabolism both in vivo and in vitro. Here we summarise the main metabolic complications, with a particular focus on the possibility that brain energy metabolism is altered following ZIKV infection, c…
The recent outbreak of the Zika virus (ZIKV) and the discovery that perinatal Zika exposure can lead to the Congenital Zika Syndrome has promoted a call for prevention measures. Due to the increased number of babies born with microcephaly, structural brain abnormalities, and neurological alterations in regions affected by ZIKV, investigations were carried out in order to better understand this process. The maternal immune system directly influences the fetal central nervous system, and complications during pregnancy have been associated with neurodevelopmental disorders. Autism spectrum disorder (ASD), a neurodevelopmental…
Conclusion: Going beyond the powerful scientific and economic arguments for urgent action to reduce the burning of fossil fuels is the strong moral imperative to protect our most vulnerable populations.
Citation: Perera FP. 2017. Multiple threats to child health from fossil fuel combustion: impacts of air pollution and climate change. Environ Health Perspect 125:141–148; http://dx.doi.org/10.1289/EHP299
Address correspondence to F.P. Perera, Department of Environmental Health Sciences, Columbia Center for Children’s Environmental Health, Columbia University Mailman School of Public Health, 722 West 168th St. …
Science today is regularly distorted to serve other ends. The religious right, for instance, claims that “creationism” should be taught in public schools as a scientific alternative to the theory of evolution. The environmentalist left, for instance, claims that science reveals genetically modified foods to be harmful to one’s health. Both groups subordinate the facts of science to other considerations, whether Biblical or ideological.
The same dishonesty is shaping the response to the Zika virus.
The Zika threat is causing great concern at the Rio Olympics, with some athletes having chosen to avoid the Games …
This experimental study in mice investigated the effect of Zika virus on adult brain cells, hoping to increase knowledge of the long-term outcomes of Zika virus on the adult brain. Zika was thought to be a short-term virus for adult humans without many long-term effects.
The researchers’ experiments in mice found that the two small areas in the adult mouse brain containing cells active in cell division can be susceptible to pronounced Zika infection leading to cell death and reduced cell division.
While healthy humans may be able to mount an effective immune response to the virus, it is possible that immunocompr…
While it may not be the most widespread Zika conspiracy theory on the internet, it’s certainly among the weirdest.
The fact-checking website Snopes revealed last Wednesday that at least a few people falsely believe Americans are immune to Zika virus, as these tweets demonstrate:
@SpeakerRyan @WashTimes Say NO to more Obama requested FAKE #Zika virus funding. American immune systems are immune to it. Virus isn’t new— Chad (@FlyOSUBuckeye1) May 22, 2016
@ABC dont spread propaganda about a non-existent threat to Americans Fake Zika war is a terrorist tactice— Barbara Adams (@SheSellsBoise) Ma…