Delays in CAR T-Cell Treatment Cost Patients, Society

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Delays in CAR T-cell therapy may significantly decrease gains in survival and productivity for patients with diffuse large B-cell lymphoma and pediatric  acute lymphoblastic leukemia.

Source: CancerNetworkCategory: Cancer & Oncology Authors: Source Type: news

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This study aimed at documenting the leukemia-associated immunophenotype (LAIP) specific for morphologic (FAB) subclasses of acute leukemia (AL). A retrospective case record-based study was carried out including 100 cases of de novo acute leukemia over 1  year to study the association of FCM immunophenotype profile with morphologic FAB classification of acute leukemia. Fourteen cases (14%) were diagnosed as acute leukemia—unclassified by morphology which were accurately classified by FCM into B cell acute lymphoblastic leukemia (ALL) (6), T cell ALL (3), acute myeloid leukemia (AML) (4), and mixed phenotype acute…

Publication date: Available online 27 August 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Weerapat Owattanapanich, Pongprueth Rujirachun, Patompong Ungprasert, Jassada Buaboonnam, Piti TechavichitAbstractBackgroundThe presence of Philadelphia (Ph)-like ALL among patients with acute lymphoblastic leukemia (ALL) may indicate a poor prognosis similar to Philadelphia positive (Ph+) ALL although the data are still inconclusive and the prevalence of Ph-like ALL varied considerably across the studies.MethodsThe current systematic review and meta-analysis were conducted with the aims to identify all cohort studies …

Publication date: Available online 26 August 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Hyunkyung Park, Ja Min Byun, Youngil Koh, Sung-Soo Yoon, Hyejoo Park, Jayoun Lee, Sang-Jin Shin, Jeonghwan YoukAbstractBackground/AimThe optimal the conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT), especially for East Asian patients, remains unknown.Patients and MethodsWe collected and analyzed clinical and survival data of 4,255 patients from the Korean National Health Insurance Claims Database.ResultsBetween 1,562 myeloablative conditioning (MAC) and 2,693 non-myeloablative conditi…

The presence of Philadelphia (Ph)-like ALL among patients with acute lymphoblastic leukemia (ALL) may indicate a poor prognosis similar to Philadelphia positive (Ph+) ALL although the data are still inconclusive and the prevalence of Ph-like ALL varied considerably across the studies.

Source: Clinical Lymphoma, Myeloma and LeukemiaCategory: Hematology Authors: Tags: Original Study Source Type: research

Publication date: Available online 22 August 2019Source: Cancer CellAuthor(s): Salma Parvin, Ariel Ramirez-Labrada, Shlomzion Aumann, XiaoQing Lu, Natalia Weich, Gabriel Santiago, Elena M. Cortizas, Eden Sharabi, Yu Zhang, Isidro Sanchez-Garcia, Andrew J. Gentles, Evan Roberts, Daniel Bilbao-Cortes, Francisco Vega, Jennifer R. Chapman, Ramiro E. Verdun, Izidore S. LossosSummaryDeficiency in DNA double-strand break (DSB) repair mechanisms has been widely exploited for the treatment of different malignances, including homologous recombination (HR)-deficient breast and ovarian cancers. Here we demonstrate that diffuse large B…

Source: Cancer CellCategory: Cancer & Oncology Source Type: research

Authors: Petrou P
Abstract
Introduction: The new category of chimeric antigen receptor T – cell raised hopes for a more effective treatment of large B cell lymphoma and acute lymphoblastic leukemia. Nevertheless, their soaring acquisition costs will stretch the fiscal capacity of the health systems worldwide. To this direction, the scope of this study is to provide a systematic review of their economic evaluations. Areas covered: A systematic review of the economic evaluations of tisagenlecleucel and axicabtagene was performed. Expert opinion: The available data indicate that these products demonstrate a potentiall…

Auer rods were first described in the cytoplasm of leukemia blasts by John Auer in 1906. Auer rods are commonly seen in myeloid progenitors, and serve as a diagnostic morphological feature of acute myeloid leukemia (AML) [1]. The differential diagnosis of hematopoietic neoplasms relies on the detection of cytoplasmic inclusions resembling Auer rods. Auer rod-like inclusions have been described in multiple myeloma [2], prolymphocytic leukemia (PLL) [3], B-cell acute lymphoblastic leukemia [4], chronic lymphocytic leukemia [4], splenic lymphoma [5] and nodal marginal zone lymphoma [6], which are quite distinct from the needl…

Source: Experimental HematologyCategory: Hematology Authors: Tags: Brief Communication Source Type: research

Publication date: Available online 12 August 2019Source: Gynecologic Oncology ReportsAuthor(s): Jamil Kazma, Cynae Johnson, Nitin Jain, Vasantha Lakshmi Gali, Ken H. Young, Amir A. JazaeriAbstractThe involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient is a 61-year-old female with history B-cell ALL and had multiple relapses confined to the bone marrow and had received several different chemotherapy regimens. She presented with lower abdominal pain after the…

Condition:   Childhood Leukemia and Lymphoma Intervention:   Sponsors:   Rabin Medical Center;   The Israeli Society for Pediatric Hematology-Oncology;   International BFM Study Group Not yet recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials



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