Modeling Seasonality Of Zika Virus

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Understanding the timing of pulse vaccinations can help in preventing Zika virus outbreaks. Researchers uncover a new seasonality effect via modeling. Winter is coming.

Source: Forbes.com Healthcare NewsCategory: Pharmaceuticals Authors: Source Type: news

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ard Hildt

Infection with Zika virus (ZIKV) came first to public attention after it was found to be associated with congenital microcephaly during the outbreak in Brazil (2015–2016). Diagnosis of ZIKV suffers from extensive cross-reactivity with other Flaviviruses, which are circulating in many ZIKV epidemic areas. Due to the fatal outcome of ZIKV infection during pregnancy, detailed knowledge about neutralizing and non-neutralizing epitopes is crucial for the development of robust detection systems of protective antibodies. Therefore, additional information about ZIKV immunogenicity and antibody response is requi…

Source: VirusesCategory: Virology Authors: Tags: Article Source Type: research

Publication date: Available online 13 June 2019Source: Antiviral ResearchAuthor(s): Anna Dubankova, Evzen BouraAbstractYellow fever virus (YFV) is responsible for devastating outbreaks of Yellow fever (YF) in humans and is associated with high mortality rates. Recent large epidemics and epizootics and exponential increases in the numbers of YF cases in humans and non-human primates highlight the increasing threat YFV poses, despite the availability of an effective YFV vaccine. YFV is the first human virus discovered, but the structures of several of the viral proteins remain poorly understood. Here we report the structure …

Zika virus (ZIKV), a mosquito-borne Flavivirus, is a positive single-stranded RNA virus with a nucleic acid length of about 10.7kb. This virus has been spreading rapidly and there have been large-scale outbreaks worldwide in recent years (Haddow et al., 2012; Harris et al., 2006; Calvet et al., 2016; Dick et al., 1952). ZIKV has drawn attention as it may cause severe symptoms while no specific medical treatment or vaccine is currently available (Campos et al., 2015; Hancock et al., 2014; Brasil et al., 2016; Cao-Lormeau et al., 2016).

Source: International Journal of Infectious DiseasesCategory: Infectious Diseases Authors: Source Type: research

Abstract
Yellow fever virus (YFV) is responsible for devastating outbreaks of Yellow fever (YF) in humans and is associated with high mortality rates. Recent large epidemics and epizootics and exponential increases in the numbers of YF cases in humans and non-human primates highlight the increasing threat YFV poses, despite the availability of an effective YFV vaccine. YFV is the first human virus discovered, but the structures of several of the viral proteins remain poorly understood. Here we report the structure of the full-length NS5 protein, a key enzyme for the replication of flaviviruses that contains both a…

Source: Antiviral ResearchCategory: Virology Authors: Tags: Antiviral Res Source Type: research

Abstract
Flaviviruses are enveloped viruses with positive-sense, single-stranded RNA, which are most commonly transmitted by infected mosquitoes. Zika virus (ZIKV) and yellow fever virus (YFV) are flaviviruses that have caused significant outbreaks in the last few years. Since there is no approved vaccine against ZIKV, and since the existing YF attenuated vaccine presents disadvantages related to limited supply and to rare, but fatal adverse effects, there is an urgent need for new vaccines to control these diseases. Virus-like particles (VLPs) represent a recombinant platform to produce safe and immunogenic vacci…

Source: VaccineCategory: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

rhard Hildt

Zika virus (ZIKV) is a highly transmissive virus that belongs to the Flaviviridae family, which comprises several other pathogens that threaten human health. This re-emerging virus gained attention during the outbreak in Brazil in 2016, where a considerable number of microcephaly cases in newborns was associated with ZIKV infection during pregnancy. Lacking a preventive vaccine or antiviral drugs, efforts have been made to better understand the viral life cycle. In light of this, the relevance of the endosomal–lysosomal compartment for the ZIKV life cycle was investigated. A549 and SH-SY5Y cells w…

Source: VirusesCategory: Virology Authors: Tags: Article Source Type: research

by Robert C. Reiner Jr., Steven T. Stoddard, Gonzalo M. Vazquez-Prokopec, Helvio Astete, T. Alex Perkins, Moises Sihuincha, Jeffrey D. Stancil, David L. Smith, Tadeuz J. Kochel, Eric S. Halsey, Uriel Kitron, Amy C. Morrison, Thomas W. Scott

During the last 50 years, the geographic range of the mosquitoAedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue. There is a growing consensus that vector control is essential to preventAedes-borne diseases, even as effective vaccines become available. What remains uncl…

Pregnant women &vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response.
Vaccine. 2019 May 03;:
Authors: Krubiner CB, Faden RR, Karron RA, Little MO, Lyerly AD, Abramson JS, Beigi RH, Cravioto AR, Durbin AP, Gellin BG, Gupta SB, Kaslow DC, Kochhar S, Luna F, Saenz C, Sheffield JS, Tindana PO, PREVENT Working Group
Abstract
Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely – and at times uniquely – affect the health interests of pregnant women and their offspring. These examples also hig…

Source: VaccineCategory: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

Viveros-Sandoval
Reyes-Sandoval

Chikungunya fever is a debilitating disease caused by Chikungunya virus (CHIKV) that can result in long-lasting arthralgias. The early diagnosis of CHIKV relies on PCR during the acute infection phase to allow differential diagnosis with other co-circulating arboviruses such as dengue and Zika. Alternatively, serology can support diagnosis and provide epidemiological information on current and past outbreaks. Many commercial serological ELISA assays are based on the inactivated whole CHIKV, but their sensitivity and specificity show great variability. We produced recombinant CHIKV E…

Source: VirusesCategory: Virology Authors: Tags: Article Source Type: research

Conclusion: Our results are similar to those reported from the state of Veracruz, Mexico, in which out of 33 samples of urine of patients with GBS two had a positive RT-PCR for ZIKV. Simultaneous processing of serum, CSF, urine, and saliva by RT-PCR may increase the success of diagnosis of GBS associated to ZIKV.



Introduction
In April 2016, a report of Epidemiological Surveillance for Zika virus (ZIKV) disease in Mexico reported 93 autochthonous laboratory-confirmed cases, collected between November 2015 and February 2016, and distributed amongst eight states of the country (1). In these patients, clinical manifest…



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