A Potential Therapy Option for Allergic Bronchopulmonary Aspergillosis (ABPA) in Asthma Patients

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Omalizumab: A Potential Therapy Option for Allergic Bronchopulmonary Aspergillosis (ABPA) in Asthma PatientsConference abstracts

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ConclusionIgE against rAsp f1 and f2 (using ROC derived cut-offs) were found to be the most useful in differentiating ABPA from ASA. Due to conduct at single-center, our results require further validation.

Publication date: Available online 5 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Hironobu Tsubouchi, Shinpei Tsuchida, Shigehisa Yanagi, Takafumi Shigekusa, Mariko Miura, Kenjiro Sakaguchi, Nobuhiro Matsumoto, Masamitsu NakazatoAbstractAllergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction that is associated with an allergic immunological response to Aspergillus species via Th2-related inflammation. The long-term use of a systemic corticosteroid is often needed for the treatment of ABPA. However, systemic corticosteroid treatment imposes a risk of the onset of a nontuberculou…

This article describes 3 cases of IPA. Two patients had a history of chronic obstructive pulmonary disease (COPD) and asthma, and the other patient had no underlying diseases. The Aspergillus fumigatus gene was found in the bronchoalveolar lavage fluid in all three cases by NGS. This report explores the role of NGS in the diagnosis of IPA and emphasizes that IPA may occur in non-neutropenic patients.
PMID: 31105860 [PubMed]

CONCLUSION: The use of multiple recombinant antigens may improve the diagnostic accuracy in CF complicated with ABPA or AB. Asp f1 reactivity may relate to the presence of actively growing Aspergillus spp., which might be a useful marker for guiding antifungal therapy in ABPA.
PMID: 31090534 [PubMed – as supplied by publisher]

Source: Journal of Medical MicrobiologyCategory: Microbiology Authors: Tags: J Med Microbiol Source Type: research

Aspergillus is the causative agent of human diseases ranging from asthma to invasive infection. Genetic and environmental factors are crucial in regulating the interaction between the host and Aspergillus. The role played by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which catalyzes the first and rate-limiting step of tryptophan catabolism along the kynurenine pathway, is increasingly being recognized, but whether and how genetic variation of IDO1 influences the risk of aspergillosis in susceptible patients is incompletely understood. In addition, whether the closely related protein IDO2 plays a similar role remains …

Conclusions
In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases.
Author Contributions
All authors listed have made a substantial, direct and i…

CONCLUSIONS: Tests using allergen components were useful for ABPA diagnosis. Both IgE and IgG were highly cross-reactive among the Aspergillus species. There were many patients apart from asthmatic patients with ABPA, who displayed high Aspergillus IgG values.
PMID: 30943819 [PubMed – as supplied by publisher]

Source: Journal of AsthmaCategory: Respiratory Medicine Tags: J Asthma Source Type: research

Allergic bronchopulmonary aspergillosis is an immunologic pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus. This disorder is most commonly seen in patients with poorly controlled asthma and cystic fibrosis. It is rarely reported in chronic granulomatous disease patients; however, there are no cases reported with hematopoietic stem cell transplantation in the English literature. Herein, we report a patient with chronic granulomatous disease who had hematopoietic stem cell transplantation and subsequently developed allergic bronchopulmonary aspergillosis.

Conclusions: RoutineA. fumigatus-sIgE screening for asthma patients can significantly improve the diagnostic rate of ABPA.Int Arch Allergy Immunol

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