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Publication date: Available online 13 September 2019Source: Veterinary ParasitologyAuthor(s): R.E.B. Hanna, D. Moffett, M.W. Robinson, W.G.Z.O. Jura, G.P. Brennan, I. Fairweather, L.T. ThreadgoldAbstractCytochemical staining techniques were carried out en bloc with in vitro excysted and gut-penetrated Fasciola gigantica larvae in order to visualise the glycocalyx of the tegument, a structure which comprises the parasite component of the host-parasite interface, yet is incompletely preserved by conventional fixation and preparation techniques for electron microscopy. Positive reactivity with ruthenium red and periodic acid-…
This article summarizes the most important treatment modalities based on case reports and series, clinical studies, guidelines and expert recommendations.
PMID: 31515578 [PubMed – as supplied by publisher]
Publication date: Available online 13 September 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xiaodong Zhai, Xiaobo Zou, Jiyong Shi, Xiaowei Huang, Zongbao Sun, Zhihua Li, Yue Sun, Yanxiao Li, Xin Wang, Melvin Holmes, Yunyun Gong, Megan Povey, Jianbo XiaoAbstractAmine-responsive bilayer films were developed by using agar (AG), anthocyanins (AN), gellan gum (GG) and TiO2 nanoparticles for visual monitoring of meat spoilage. The AG-AN layer worked as the sensing layer to volatile amines, while GG-TiO2 layer served as the light barrier layer and simultaneously the conducting layer to improve the illumination stabili…
BACKGROUND: In the past years numerous studies have investigated the efficacy of baclofen for alcohol dependence. After publication of several reviews a number of new randomized controlled trials have been published. Two recent meta-analyses, based on largely the same studies, reported contrary results. One meta-analysis showed a positive effect on time to relapse and abstinence at endpoint. The other meta-analysis did not show an effect on the primary outcome measures. AIM: To clarify the clinical relevance of the effect of baclofen on alcohol use in patients with a disorder in the use of alcohol, in the…
Authors: Gameon JA, Skewes MC
American Indian/Alaska Native and First Nations communities suffer from health disparities associated with multiple forms of trauma exposure. Culturally appropriate interventions are needed to heal current and historical trauma wounds. Although there are evidence-based trauma interventions for other populations, few have been implemented or evaluated with Native communities. Understanding the extant research on trauma interventions in Native communities is crucial for advancing science and filling gaps in the evidence base, and for meeting the needs of underserved people. In t…
Although Ethiopia has an overall lower prevalence of Plasmodium falciparum among countries in Africa, the emergence of drug resistance could seriously hinder elimination efforts. Using samples collected from five therapeutic efficacy studies conducted in 2007-11, we evaluated the prevalence of putative drug resistance mutations in the pfcrt, pfmdr1, and kelch13 genes at the time of those studies, as well as the ama1 gene for genetic relatedness using a pooled amplicon deep sequencing approach. Among all sites, the kelch13 gene showed no mutations, whereas the pfcrt CVIET genotype was fixed in all populati…
Strongyloidiasis, caused by Strongyloides stercoralis infection, is an important neglected tropical disease that causes significant public health problems in the tropics and subtropics. The disease can persist in hosts for decades and may be life-threatening because of hyperinfection and dissemination. Ivermectin (mostly) and albendazole are the most common anthelmintics used for treatment. Albendazole is suboptimal for this parasite, and although ivermectin is quite effective in immunocompromised patients, a multiple-course regimen is required. Furthermore, reliance on a single drug class for treating in…
Rocky Mountain spotted fever (RMSF), caused by Rickettsia rickettsii, is a severe tick-borne infection endemic to the Americas. Oral doxycycline is effective, but during severe life-threatening disease, intravenous therapy is recommended. Unfortunately, intravenous formulations of doxycycline are not always available. Therefore, we aimed to determine the susceptibility of R. rickettsii to an alternative parenteral agent, tigecycline, in vitro and in vivo. To determine the minimum inhibitory concentration of tigecycline, R. rickettsii-inoculated Vero cells were incubated with medium containing tigecycline….
Publication date: Available online 13 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Emmanuel Ledoult, Matthieu Groh, Jean-Emmanuel Kahn, Jacques Trauet, Jean-David Bouaziz, Aurélie Caristan, Vincent Cottin, Sylvain Dubucquoi, Nicolas Etienne, Cécile Golden, Perrine Guillaume-Jugnot, Éric Hachulla, David Launay, Irène Machelart, Adèle De Masson, Thomas Molinet, Chafika Morati-Hafsaoui, Marie Puget, Mathilde Roumier, Louis Terriou
CONCLUSION: There are four distinct youth alcohol-use patterns. The high probability of transitioning to drinking during the secondary school years suggests the need for preventive interventions in earlier stages of use, before drinking becomes habitual.
PMID: 31517467 [PubMed – in process]