[The Herald] Health and Child Care Ambassador, First Lady Auxillia Mnangagwa yesterday commended the National Aids Council of Zimbabwe for donating cervical cancer screening machines to the Ministry of Health and Child Care.
Conclusion: MN scoring on the epithelial cells of buccal mucosa can be used as a biomarker in screening procedures for HIV patients.
Roche has expanded the Global Access Program, originally established to increase availability of HIV diagnostics in underserved countries, to include diagnostic tests for tuberculosis, hepatitis, and human papillomavirus (HPV). Increased access to reliable diagnostics will allow early, possibly life-saving, detection and decrease the spread of these diseases.
Roche launched the program in 2014 and began offering the added tests in July. The molecular diagnostics available include tests for determination of HIV-1 viral load, early diagnosis of HIV-1 and -2 in young infants, Mycobacterium tuberculosis (MTB) and rifampin/ison…
FINDINGSBased on a 2017 rate of vaccination against HPV among a group of California 20-year-olds, researchers estimate that this group is at risk for an excess of 1,352 cases of cancer that could be prevented with a 99.5% vaccination rate. Treatment for these preventable cancers would cost the health care system $52.2 million. The size of the group was 296,525 people, the approximate number of 20-year-olds in California in 2017.BACKGROUNDHuman papillomavirus, or HPV, is the most common sexually transmitted infection in the United States and is linked to seven types of cancer: cervical, vaginal, vulvar, penile, rectal, anal…
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Conditions: Uterine Cervical Neoplasms; HIV/AIDS Intervention: Diagnostic Test: Screening for HSIL Sponsors: University of Bern; Centre for Infectious Disease Research in Zambia; Cervical Cancer Prevention Program in Zambia; International Agency for Research on Cancer Not yet recruiting
Conclusion: 3T3-L1 cells, treated with LPV/RTV, show altered lipid content due to increased miRNA-218 levels, which affects lipin-1 mRNA. Moreover, increased miRNA-218 levels were inversely correlated with changes in GLUT-4 expression, which suggests a role for miRNA-218 in mediating the insulin resistance consequent to cART.
Metabolic syndrome is a serious consequence of combined Antiretroviral Therapy (cART). HIV-associated metabolic syndrome is often accompanied by lipodystrophy (LS), the redistribution of body fat with loss of subcutaneous adipose tissue in face, limbs and buttocks, concomitant wit…
In this study, β2∗ nAChR-containing receptors and lynx1 were identified using pull down studies from the mouse brain (Nissen et al., 2018), while ws-lynx1, SLURP-1 and SLURP-2 has been successfully mixed with human brain tissue to pull down multiple nAChR subtypes (Lyukmanova et al., 2016a,b; Thomsen et al., 2016). To support the in vivo interaction studies, a lynx1KO phenotype was ameliorated by crossing these mice into mutant mice null for α7 and β2 nAChR genes (Miwa et al., 2006). These in vivo studies provide an important biological context for the interactions observed within in vitro systems.
Conclusions and Perspectives
It is interesting that watershed events, such as the loss of Neu5Gc from the glycocalyx of human cells have occurred numerous times in many mammalian and other vertebrate species. These cases of convergent evolution represent precious opportunities for increased understanding of evolutionary processes. In some respects, Neu5Gc is an ideal self-molecule as it is “private” to vertebrates and, based on current data, has yet to be successfully mimicked by microbes. Against the background of this benefit, the loss of Neu5Gc appears paradoxical and may implicate strong selective regimes,…
Segun Fatumo1,2,3*, Tommy Carstensen4, Oyekanmi Nashiru3, Deepti Gurdasani4†, Manjinder Sandhu4,5† and Pontiano Kaleebu1,2†
1Uganda Medical Informatics Centre, MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda
2London School of Hygiene and Tropical Medicine, London, United Kingdom
3H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria
4Human Genetics, Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom
5Division of Computational Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kin…
In this study, we investigated the impact of the human ALK-F1174L mutation in vivo on sympathetic neuroblast differentiation using Sox10-Cre;LSL-ALK-F1174L mice. The aim was to improve our understanding of the implication of ALK deregulated signaling in the initial steps of NB genesis.
ALK-F1174L Causes Embryonic Lethality When Expressed in NCCs Prior to SA Lineage Commitment
To assess the impact of the human ALK-F1174L activating mutation on the development and differentiation of the SNS, Sox10-Cre;LSL-ALK-F1174L embryos were generated. This model allowed to restrict the expression of the ALK-F1174L variant to …