Mycafungin Prophylaxis for Adult Acute Leukemia Patients Undergoing Induction ChemotherapyConference abstracts
Case Report: A 63-year-old man had been diagnosed of chronic myelomonocytic leukemia on 2015 which was asymptomatic and not treated. On 2017, he presented abruptly with skin lesions that looked like bruises but were infiltrated and affected the face and upper back. Cutaneous and bone marrow biopsy ruled out leukemia cutis and it was diagnosed of blastic plasmacytoid dendritic cell neoplasm (BPDCN). Therefore he started chemotherapy using the protocol for acute lymphoblastic leukemia ALL OLD>55 years.
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs.
Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp…
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation.
Regulation of Complement Activation
PTX3 interaction with microorganisms is not…
SR Safai Nodeh, SA Dehghan Manshadi, B Jahanbin, S Khodaveisi, F Giasvand, A Seifi, M SalehiNigerian Journal of Clinical Practice 2019 22(4):582-584
A woman with AML who became febrile and neutropenic after chemotherapy. At the first, Aspergillus was isolated from a sinus biopsy. After 4 weeks, while she was taking voriconazole, another episode of fever combined with dry coughs was detected. Fungal culture and histopathology of sinus biopsy revealed mucormycosis.
We report that the bifunctional compounds enhance the interactions between primary human neutrophils and A. fumigatus in vitro, using three microfluidic assay platforms. The bifunctional compounds significantly enhance the recruitment of neutrophils, increase hyphae killing by neutrophils in a uniform concentration of drug, and decrease hyphal tip growth velocity in the presence of neutrophils compared to the antifungal targeting moiety alone. We validated that the bifunctional compounds are also effective in vivo, using a zebrafish infection model with neutrophils expressing the appropriate EM receptor. We measured signif…
Conclusions: Although Hyper-CVAD and PE THEMA ALL-93 showed similar effects, Hyper-CVAD was tolerated better. Age and comorbidities should be taken into account before a chemotherapy regimen is determined for patients with ALL.Chemotherapy 2018;63:207 –213