Robert Chelsea turned down the first face he was offered. It was a fine face, one that could have taken him off the transplant waiting list after just a couple months. But Chelsea—severely disfigured after a catastrophic car accident five years earlier—was in no hurry. He’d gotten used to tilting his head back so food and water wouldn’t fall out of his nearly lipless mouth. He knew how to respond compassionately to children who stared in shock and fear. The face, offered in May 2018, had belonged to a man with skin that was much fairer than what remained of Chelsea’s—so light that Chelsea, who is African American, couldn’t bear the thought of becoming “a totally different looking person.”
Chelsea’s doctors understood his hesitance. Face transplants in general are rare. Since the first partial one was performed in France in 2005, fewer than 50 have been completed worldwide. A new patient joining the ranks is always noteworthy, but Chelsea’s case carries even more weight than usual. Because he is the first African American to receive a full face transplant, Chelsea’s treatment is expected to have ripple effects that transcend his case. Disparities in the medical system that cause black Americans to die at higher rates than whites of so many things—like heart disease, cancer diabetes and HIV/AIDS—have also produced gaps in organ donation and transplantation. Widespread mistrust of the medical sy…
Authors: Krebs P, Borchers J
A 13-year-old female soccer and basketball athlete presented with pain in the arch of her foot. Magnetic resonance imaging confirmed the diagnosis of a middle cuneiform stress fracture. The patient’s stress fracture healed nonoperatively over a 10-week period complicated by nonadherence to a fracture boot, after which she was progressed back to full activity. Knowledge of these fractures and their treatment are important for sports medicine physicians, as they can often be overlooked, given their infrequent occurrence. There have been 8 previous case reports and 1 case series o…
Authors: Priglinger C, Klopstock T, Rudolph G, Priglinger SG
Leber’s hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur at any age and also in women. LHON is caused by point mutations in the mitochondrial DNA, which lead to a defect in complex I of the mitochondrial respiratory chain. This in turn causes dysfunction and later degeneration of retinal ganglion cells, followed by ascending optic atrophy. Classically, LHON presents as a subacute unilateral loss of visual acuity, dyschromatopsia in the red-green axis and a central or centr…
Contemporary research has taught us a great deal about both the mechanism of chronic radiation exposure ’s close relationship with cancer and the implications of this mechanism for individuals. We know that x-rays and other forms of ionizing radiation can cause DNA breakage and other forms of molecular damage (eg, nucleotide substitution and sugar ribose alterations). In turn, these molecular insult s can result in acquired mutations that affect gene function and protein expression. Importantly, the duration and intensity of radiation exposure tracks with the extent of DNA damage.
Be forewarned, before you get too far into this post, you will likely think I’m a dummy. I’m also not anticipating hearing what I hope to hear, but want to ask anyway.
That being said, I’m a DO. I matched into my top choice ACGME FM program in 2016. I completed about 21 months of it and resigned. There were many different reasons, but mostly I just couldn’t take another day of family medicine. I thought about the decision for well over a year and pushed myself as far as I could go hoping I…
Resigned from FM residency after 21 months, any chance of anesthesiology?
Colon cancer rates and pancreatic cancer deaths rose by 10% worldwide between 1990 and 2017, according to a new study of global trends in digestive diseases.
Publication date: Available online 22 October 2019Source: SeizureAuthor(s): Donald P. Craig, Tejal N. Mitchell, Rhys H. ThomasAbstractIn status epilepticus the imperative to start anti-seizure therapy, initially subjugates the need to investigate the cause. Once treatment is initiated this balance shifts in favour of identifying: the causes and consequences of the seizure; the factors that predetermined the occurrence of status epilepticus; and finally the prognosis of this acute episode. Just as there are multiple causes of seizures and epilepsy, there are a vast number of causes of status epilepticus. We discuss the more…
TYPE 2 diabetes requires someone to overhaul aspects of their lifestyle to keep blood sugar levels from spiking. Snacking can make this harder. Here are four tips to avoid snacking throughout the day.
ConclusionCHIP may not only function as a key regulator of protein quality control but also a critical deciding factor to oral fibrogenesis. Our findings suggested that CHIP possesses the anti-fibrotic effect, which may be mediated by TGM2 regulation. Restoration of CHIP could be a therapeutic direction to help OSF patients.
Climate change is making it harder to eradicate deadly epidemics, with rising temperatures helping mosquitoes spread malaria in higher places in Africa, the head of a global health fund said on Tuesday.Reuters Health Information
This article summarizes current clinical approaches in patients with pheochromocytoma/paraganglioma.