Critical protein that could unlock West Nile/Zika virus treatments identified

(Georgia State University) A team of Georgia State scientists has identified a protein that is critical in controlling replication of West Nile and Zika viruses — and could be important for developing therapies to prevent and treat those viruses.

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Publication date: Available online 7 November 2019Source: Chemical Engineering JournalAuthor(s): Benita Ortega-Berlanga, Luis Hernández-Adame, César del Angel-Olarte, Fernanda Aguilar, Sergio Rosales-Mendoza, Gabriela PalestinoAbstractNew adjuvants are required in the field of vaccinology to enhance the immunogenicity and efficacy of subunit vaccines, which constitute a safer approach to protect against infectious diseases compared to whole pathogen-based vaccines. In the present study, rare-earth upconverting microparticles were explored as possible antigen carriers with adjuvant properties by using a peptid…

The first native cases of Zika in Europe have been confirmed after three people became infected with the virus in France. Experts warn that climate change could lead to more cases emerging across the continent.

Source: – HealthCategory: Consumer Health News Source Type: news

CONCLUSIONS: Ophthalmic signs/symptoms of Zika infection can help the clinical diagnosis of these arbovirosis.
PMID: 31679764 [PubMed – as supplied by publisher]

This study describes the efforts and outcomes associated with the establishment of a clinical sample repository during the 2016 Zika virus epidemic. To overcome the challenge of limited access to clinical samples to support diagnostic test development, multiple US Department of Health and Human Services (HHS) agencies formed a partnership to create the HHS Zika Specimen Repository. In 2016-2017, the Biomedical Advanced Research and Development Authority and the Centers for Disease Control and Prevention collected patient specimens (4420 convalescent sera aliquots from 100 donors and 7171 plasma aliquots from 239 donors), c…

Source: Public Health ReportsCategory: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Authors: Villanueva J, Schweitzer B, Odle M, Aden T
The Laboratory Response Network (LRN) was established in 1999 to ensure an effective laboratory response to high-priority public health threats. The LRN for biological threats (LRN-B) provides a laboratory infrastructure to respond to emerging infectious diseases. Since 2012, the LRN-B has been involved in 3 emerging infectious disease outbreak responses. We evaluated the LRN-B role in these responses and identified areas for improvement. LRN-B laboratories tested 1097 specimens during the 2014 Middle East Respiratory Syndrome Coronavirus outbreak, 180 sp…

Source: Public Health ReportsCategory: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Authors: Heberlein-Larson L, Gillis LD, Morrison A, Scott B, Cook M, Cannons A, Quaye E, White S, Cone M, Mock V, Schiffer J, Lonsway D, Petway M, Otis A, Stanek D, Hamilton J, Crowe S
The emergence of Zika virus in the Americas in 2015 and its association with birth defects and other adverse health outcomes triggered an unprecedented public health response and a demand for testing. In 2016, when Florida exceeded state public health laboratory capacity for diagnostic testing, the state formed partnerships with federal and commercial laboratories. Eighty-two percent of the testing (n = 33 802 of 41&t…

Source: Public Health ReportsCategory: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Date: Thursday, 11 07, 2019; Speaker: Gavin Screaton, MD, DPhil, Professor and Head of Medical Sciences Division, Nuffield Department of Medicine, University of Oxford; Building: Building 50; 12271233

Cognitive development of infants with prenatal exposure to Zika virus but without microcephaly is similar to that of unexposed infants, according to a study of Puerto Rican infants.Reuters Health Information

Conclusions/SignificanceOur findings highlight the need for furtherin vivo studies that more closely recapitulate natural arbovirus transmission settings in which arboviruses encounter mosquitoes harbouring persistent rather than acute insect-specific virus infections. Furthermore, we provide the well-characterised Aag2-derived clonal cell line as a valuable resource to the arbovirus research community.

Publication date: Available online 4 November 2019Source: Antiviral ResearchAuthor(s): Michael Basic, Fabian Elgner, Daniela Bender, Catarina Sabino, Marie-Luise Herrlein, Hanna Roth, Mirco Glitscher, Alicia Fath, Thomas Kerl, Hans-Günther Schmalz, Eberhard HildtAbstractZika virus (ZIKV) is a re-emerging virus belonging to the family of Flaviviridae, which contains several human pathogens. A great deal of attention came through the association of ZIKV infection with an increasing number of microcephaly cases in newborns during the 2016 outbreak in Brazil. Currently, no anti-viral drug or vaccine is available.Houttuyno…

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