Integral Molecular to advance vaccine discovery with NIH contract for $5.5 million

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(Integral Molecular) The NIH has awarded Integral Molecular a contract which will provide up to $5.5M over the next five years to define antibody responses to pathogenic viruses including Zika, Marburg and equine encephalitis viruses (EEV), aiding the discovery of vaccines and therapeutics against these currently untreatable and often lethal viruses.

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This article updates our laboratory’s systematic search for antigens using bioinformatics tools to clarify the Mtb H37Rv Rv3632 protein’s topology and location. This article reports a C-terminal region consisting of peptides 39255 and 39256 (81Thr-Arg114) having high specific binding regarding two infection-related cell lines (A549 and U937); they inhibited mycobacterial entry to U937 cells in a concentration-dependent manner. Rv3632 forms part of the mycobacterial cell envelope, formed by six linear synthetic peptides. Circular dichroism enabled determining the protein’s secondary structure. It was also found that peptide…

Source: Biomed ResCategory: Research Authors: Tags: Biomed Res Int Source Type: research

[Nation] Kenya is on course in the immunisation of 800,000 girls against cervical cancer, Health Cabinet Secretary Sicily Kariuki has said, and allayed fears about the safety of the vaccine.

(University of Maryland) In the first study of public health-related Facebook advertising, newly published in the journal Vaccine, researchers at the University of Maryland, the George Washington University and Johns Hopkins University show that a small group of anti-vaccine ad buyers has successfully leveraged Facebook to reach targeted audiences and that the social media platform’s efforts to improve transparency have actually led to the removal of ads promoting vaccination and communicating scientific findings.

Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Colin Havenar-Daughton, Diane G. Carnathan, Archana V. Boopathy, Amit A. Upadhyay, Ben Murrell, Samantha M. Reiss, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Pallavi Dhadvai, Federico Viviano, Kirti Kaushik, Jinal N. Bhiman, Bryan Briney, Dennis R. Burton, Steven E. Bosinger, William R. Schief, Darrell J. Irvine, Guido Silvestri, Shane CrottySummaryThe first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes (LNs), we …

Source: Cell ReportsCategory: Cytology Source Type: research

Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Laura R.H. Ahlers, Chasity E. Trammell, Grace F. Carrell, Sophie Mackinnon, Brandi K. Torrevillas, Clement Y. Chow, Shirley Luckhart, Alan G. GoodmanSummaryThe World Health Organization estimates that more than half of the world’s population is at risk for vector-borne diseases, including arboviruses. Because many arboviruses are mosquito borne, investigation of the insect immune response will help identify targets to reduce the spread of arboviruses. Here, we use a genetic screening approach to identify an insulin-like receptor as a…

Source: Cell ReportsCategory: Cytology Source Type: research

Volume 47, Issue 1, December 2019, Page 4182-4193 .

Publication date: Available online 13 November 2019Source: Veterinary MicrobiologyAuthor(s): Linlin Li, Yun Zhang, Jiawen Dong, Junqing Zhang, Chunhong Zhang, Minhua Sun, Yongchang CaoAbstractDuck Tembusu virus (DTMUV) is a major pathogen of duck industry in China. In the current study, we generated different constructs containing envelope (E) protein, pre-membrane-envelope (prM-E) protein, and C-terminally truncated E protein of the DTMUV. The constructed proteins could induce specific antibody responses in young ducks. When ducklings were immunized with the constructed proteins, they were 100% protected against DTMUV inf…

Publication date: Available online 15 December 2017 Source:Antiviral Research Author(s): Julia Ma, Xuexiang Zhang, Veronica Soloveva, Travis Warren, Fang Guo, Shuo Wu, Huagang Lu, Jia Guo, Qing Su, Helen Shen, Eric Solon, Mary Ann Comunale, Anand Mehta, Ju-Tao Guo, Sina Bavari, Yanming Du, Timothy M. Block, Jinhong Chang Targeting host functions essential for viral replication has been considered as a broad spectrum and resistance-refractory antiviral approach. However, only a few host functions have, thus far, been validated as broad-spectrum antiviral targets in vivo. ER α-glucosidases I and II have been demonstra…

Source: Antiviral TherapyCategory: Virology Source Type: research

Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.
Antiviral Res. 2017 Dec 15;:
Authors: Ma J, Zhang X, Soloveva V, Warren T, Guo F, Wu S, Lu H, Guo J, Su Q, Shen H, Solon E, Comunale MA, Mehta A, Guo JT, Bavari S, Du Y, Block TM, Chang J
Abstract
Targeting host functions essential for viral replication has been considered as a broad spectrum and resistance-refractory antiviral approach. However, only a few host functions have, thus far, been validated as broad-spectrum antiviral targets in vivo. ER α-glucosidase…

Source: Antiviral ResearchCategory: Virology Authors: Tags: Antiviral Res Source Type: research

Publication date: Available online 10 November 2016 Source:Antiviral Research Author(s): Justin G. Julander, Venkatraman Siddharthan, Joe Evans, Ray Taylor, Kelsey Tolbert, Chad Apuli, Jason Stewart, Preston Collins, Makda Gebre, Skot Neilson, Arnaud Van Wettere, Young-Min Lee, William P. Sheridan, John D. Morrey, Y.S. Babu Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns after congenital infection underscore an urgent need for antiviral interventions. The adenosine analog BCX4430 has broad-spectrum activity again…

Source: Antiviral TherapyCategory: Virology Source Type: research

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