25 years of learning to combat cervical cancer

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(National Centre for Biological Sciences) A recent paper from the lab of Professor Sudhir Krishna at the National Centre for Biological Sciences, Bangalore, reviews the progress made in cervical cancer research over the past 25 years. This extensive coverage published in the journal of Experimental Cell Research highlights the role of a popular signaling molecule called Notch in human cervical cancer progression.

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Authors: Demers AA, Brenner DR, Smith L, Shaw A
Abstract
Examining incidence trends of all cancers combined in order to understand cancer trends can be misleading, as patterns can vary across individual cancer types. This paper highlights findings on trends over time from Canadian Cancer Statistics 2019, as measured by the annual percent change (APC) of age-standardized incidence rates. Among the results were a recent increase in thyroid cancer in males (APC: 6.4%, 1997-2015), as well as decreases in prostate cancer (APC: -9.1%, 2011-2015) and cervical cancer (APC: -3.3%, 2010-2015).
PMID: 31729314 [PubMed – in process]

Publication date: December 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 6Author(s):

ConclusionsPractical difficulties in quantifying quality of life losses and healthcare expenditures owing to competing risks in life years gained can be overcome. Their inclusion can have a substantial impact on the cost-effectiveness of cancer screening programs.

ConclusionsA considerable proportion of women did not have adequate prior screening by age 65 years. Of these, a large proportion did not receive screening after age 65 years, except those who had a recent abnormal screening result. Further research is needed to understand barriers for guideline adherence and rationales for clinical decision making.

Conditions:   Cervical Cancer;   Psychological Distress;   Coping Skills Interventions:   Other: Psychoeducation;   Other: Relaxation;   Other: Cognitive Restructuring;   Other: Solving Problems Sponsor:   National Institute of Cancerología Not yet recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials

Gynecologic cancers impact women of all ages. Some women may wish to preserve their capacity for future childbearing. With appropriate patient selection, acceptable oncologic outcomes may be achieved with preservation of fertility. Determination of eligibility for fertility preservation is guided by patient factors, tumor histology, and preoperative local staging with pelvic MR imaging. The aim of this article is to educate radiologists on the current guidelines for fertility-sparing techniques in women with early stage cervical, endometrial, and ovarian malignancies.

ConclusionsOral HPV infection is significantly prevalent and widespread worldwide, particularly among men and among populations at risk. Prevalence has increased during the last two decades.

Research by the Oral Health Foundation showed that two-thirds of Britons don’t realise that HPV is contracted through sexual contact. HPV can trigger cancer in the mouth, throat and cervix.

Publication date: Available online 15 November 2019Source: Biotechnology ReportsAuthor(s): Pradeep Kumar, Balwant Singh, Vikram Thakur, Abhishek Thakur, Nandita Thakur, Deepak Pandey, Duni ChandAbstractTaxol® (generic name Paclitaxel) is a chemotherapeutic drug, effective against head, neck, breast, lung, bladder, ovary, and cervix cancers. Rising demands in chemotherapy and limited supply of natural taxol have ultimately increased the cost of the drug. Semi synthesis using taxol precursors is not able to meet the global supply and has intensified the need to find alternative ways of taxol production. In the present st…

Gynecologic malignancies are among the most prevalent cancers affecting women worldwide, but they are heterogeneous diseases with varying risk factors, management paradigms, and outcomes. Gynecologic cancers mediated by human papillomavirus (HPV) are preventable and curable with early detection and treatment. Dramatic reductions in cervical cancer incidence and mortality have been achieved through cancer screening and HPV vaccination. Radiotherapy plays a central role in the management of gynecologic malignancies. For some cancers, radiotherapy alone can be curative. More often, radiotherapy is used in conjunction with sur…

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