The role of environmental fungus in CF aspergillosis

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The role of environmental fungus in CF aspergillosisConference abstracts

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Authors: Ikegami H, Yamasaki K, Kawanami T, Fukuda K, Akata K, Nakamura M, Ikushima I, Fukuda Y, Noguchi S, Yatera K
Abstract
A 67-year-old man with a pulmonary cavity was admitted to our hospital. Mycobacterial culture of the bronchoalveolar lavage fluid sample obtained from the right upper pulmonary lesion tested positive for mycobacterium, and sequencing of the 16S rRNA genes, hsp65, and rpoB revealed that the cultured mycobacterium was Mycobacterium parascrofulaceum. Treatment with antimycobacterial agents was ineffective, and repeated culturing of bronchoscopic specimens revealed that the specimens were positi…

Source: Internal MedicineCategory: Internal Medicine Tags: Intern Med Source Type: research

Abstract
Azole antifungals resistance in Aspergillus fumigatus is a worldwide concern. As in most public hospitals in Brazil, antifungal susceptibility tests are not routinely performed for filamentous fungi at our Institution. A 4 years retrospective azole antifungal resistance screening revealed the two azole-resistant A. fumigatus clinical isolates carrying CYP51A TR34/L98H/S297T/F495I mutation resistance mechanism obtained from two unrelated patients. Broth microdilution antifungal susceptibility showed high MICs for Itraconazole, Posaconazole, and Miconazole. STR typing analysis presented high similarity betw…

Source: Antimicrobial Agents and ChemotherapyCategory: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research

Reclassification of aspergillosis phenotype in adult CF patients&10 year follow up dataConference abstracts

Fungal rhinosinusitis, including sinonasal aspergillosis (SNA) and sino-orbital aspergillosis (SOA), is the most common type of aspergillosis encountered in cats. Other focal forms of aspergillosis including disseminated invasive aspergillosis occur less frequently. SOA is an invasive mycosis that is increasingly recognized and is most commonly caused by Aspergillus felis, a close relative of Aspergillus fumigatus. SNA can be invasive or noninvasive and is most commonly caused by A fumigatus and Aspergillus niger. Molecular methods are required to correctly identify the fungi that cause SNA and SOA. SNA has a favorable pro…

IMPROVING ANTI-FUNGAL STEWARDSHIP AND THE MANAGEMENT OF CHRONIC PULMONARY ASPERGILLOSIS THROUGH A COMPLEX LUNG INFECTION MDTConference abstracts

THE INFLUENCE OF THE CFTR MODULATOR IVACAFTOR ON ASPERGILLOSIS IN CYSTIC FIBROSISConference abstracts



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