Monkey Study Gives Hope for Zika Vaccine That Might Shield the Fetus

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MONDAY, Dec. 23, 2019 — An experimental Zika virus vaccine that was given before pregnancy protected monkey fetuses, researchers say.
The Zika DNA vaccine VRC5283 lowered levels of Zika virus in pregnant rhesus macaques and reduced the risk of…

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(NIH/National Institute of Allergy and Infectious Diseases) An experimental Zika vaccine lowered levels of virus in pregnant monkeys and improved fetal outcomes in a rhesus macaque model of congenital Zika virus infection, according to a new study in Science Translational Medicine. Scientists developed the experimental vaccine and currently are evaluating it in a Phase 2 human clinical trial. The vaccine uses a small circular piece of DNA, or plasmid, containing genes that encode Zika virus surface proteins to induce an immune response.

Zika virus (ZIKV) infection of pregnant women is associated with congenital Zika syndrome (CZS) and no vaccine is available, although several are being tested in clinical trials. We tested the efficacy of ZIKV DNA vaccine VRC5283 in a rhesus macaque model of congenital ZIKV infection. Most animal vaccine experiments have a set pathogen exposure several weeks or months after vaccination. In the real world, people encounter pathogens years or decades after vaccination, or may be repeatedly exposed if the virus is endemic. To more accurately mimic how this vaccine would be used, we immunized macaques before conception and the…

Source: Science Translational MedicineCategory: Biomedical Science Authors: Tags: Research Articles Source Type: research

(University of Texas Medical Branch at Galveston) Researchers from The University of Texas Medical Branch at Galveston showed, for the first time, that a single, higher dose of vaccination to a pregnant mouse safely protects both her and her fetus from the Zika virus.The researchers found that a single, less potent dose was not enough to protect the fetus. The findings are currently available in Nature Communications.

As the need to fairly address pregnant women ’s health interests in vaccine research is increasingly recognized, it is necessary to understand attitudes regarding research participation during pregnancy. Through the lens of hypothetical Zika virus vaccine trials, we sought to characterize how different forms and levels of evidence affect wom en’s perceptions about enrollment in vaccine research during pregnancy.

Lu Lu

Recently, Zika virus (ZIKV) has attracted much attention in consideration of its association with severe neurological complications including fetal microcephaly. However, there are currently no prophylactic vaccines or therapeutic drugs approved for clinical treatments of ZIKV infection. To determine the potential anti-ZIKV inhibitors, we screened a library of clinical drugs with good safety profiles. Erythromycin estolate (Ery-Est), one of the macrolide antibiotics, was found to effectively inhibit ZIKV infection in different cell types and significantly protect A129 mice from ZIKV-associated neurological sign…

Source: VirusesCategory: Virology Authors: Tags: Article Source Type: research

ConclusionStudies of vaccines against ZIKV are progressing positively, and in their designs, modifications of the antigens are being considered so that they do not cause cross reactions with other flaviviruses that can cause complications in people previously exposed to other flaviviruses

Authors: Wilder-Smith A, Preet R, Brickley EB, Ximenes RAA, Miranda-Filho DB, Turchi Martelli CM, Araújo TVB, Montarroyos UR, Moreira ME, Turchi MD, Solomon T, Jacobs BC, Villamizar CP, Osorio L, de Filipps AMB, Neyts J, Kaptein S, Huits R, Ariën KK, Willison HJ, Edgar JM, Barnett SC, Peeling R, Boeras D, Guzman MG, de Silva AM, Falconar AK, Romero-Vivas C, Gaunt MW, Sette A, Weiskopf D, Lambrechts L, Dolk H, Morris JK, Orioli IM, O’Reilly KM, Yakob L, Rocklöv J, Soares C, Ferreira MLB, Franca RFO, Precioso AR, Logan J, Lang T, Jamieson N, Massad E
Abstract
Zika Preparedness Latin American Network …

Source: Global Health ActionCategory: International Medicine & Public Health Tags: Glob Health Action Source Type: research

Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-αβR-/- Mice.
Cell Host Microbe. 2019 Oct 22;:
Authors: Larocca RA, Mendes EA, Abbink P, Peterson RL, Martinot AJ, Iampietro MJ, Kang ZH, Aid M, Kirilova M, Jacob-Dolan C, Tostanoski L, Borducchi EN, De La Barrera RA, Barouch DH
Abstract
Maternal infection with Zika virus (ZIKV) can lead to microcephaly and other congenital abnormalities of the fetus. Although ZIKV vaccines that prevent or reduce viremia in non-pregnant mice have been described, a maternal vaccine that provides comp…

Source: Cell Host and MicrobeCategory: Microbiology Authors: Tags: Cell Host Microbe Source Type: research

Abstract
Zika virus infection during pregnancy is associated with severe birth defects including microcephaly in the new born. The lack of specific treatment calls for the development of a safe and effective vaccine for use in pregnant women. We recently tested the efficacy of a Virus Like Particle (VLP) vaccine for Zika virus in mice and found that Capsid-preMembrane-Env (CprME) VLPs generated a better neutralizing antibody response than preMembrane-Env (prME) VLPs. The superiority of CprME VLPs suggested that inclusion of capsid in the vaccine may enhance the immune response. However, production of CprME VLPs re…

Source: VaccineCategory: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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For the first 60 years following its isolation, Zika virus (ZIKV) remained a relatively poorly described member of the Flaviviridae family. However, since 2007, it has caused a series of increasingly severe outbreaks and is now associated with neurological symptoms such as Guillain-Barré syndrome and congenital Zika syndrome (CZS). A number of reports have improved our understanding of rare complications that may be associated with ZIKV infection in adults, the areas of the body to which it spreads, and viral persistence in various tissues. Likewise, studies on the effect of ZIKV infection during pregnan…

Source: VirusesCategory: Virology Authors: Tags: Review Source Type: research



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