Could 1 Dose of HPV Vaccine Be Enough?


First introduced in 2006, the multi-dose human papillomavirus (HPV) vaccine can prevent most cervical and anal cancers among children and young adults exposed to the virus. It can also prevent the majority of both HPV-driven oral and penile cancers.

Source: WebMD HealthCategory: Consumer Health News Source Type: news

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ConclusionSpecific tolerance against the oncolytic virus enhances the efficacy of virotherapy both in monotherapy and in combination with immunotherapy.

ConclusionsHS acts by impeding the G2 to M transition of prostate cancer cells. It is likely that the mode of action is transcriptionally suppressing proteins governing mitotic entry, without eliciting significant DNA damage.Graphical abstract

ConclusionsRFO contains highly active compounds that enhance NO production through Akt- or AMPK-mediated eNOS phosphorylation. It is possible that the increase in endothelial NO production is one molecular mechanism responsible for the therapeutic effects of RFO.Graphical abstract

Publication date: Available online 28 December 2019Source: Canadian Journal of CardiologyAuthor(s): David Bobrowski, Sivisan Suntheralingam, Oscar Calvillo-Argüelles, Maria Michalowska, Eitan Amir, R. Sacha Bhatia, Paaladinesh Thavendiranathan, Husam Abdel-QadirAbstractBackgroundThere are limited data on the yield of routine cardiac imaging for trastuzumab-treated breast cancer patients.MethodsWe conducted a retrospective cohort study of breast cancer patients treated with adjuvant trastuzumab between 2007-2012 at Princess Margaret Cancer Centre (Toronto, Canada). We classified imaging tests as clinically prompted or …

Publication date: Available online 28 December 2019Source: Seminars in Cancer BiologyAuthor(s): Shawn Baldacchino, Godfrey GrechAbstractCancer metastasis is the leading cause of cancer-related mortality. The metastatic process involves measurable cellular changes that confer migratory potential, proliferative advantage and the ability to colonise a distinct microenvironment. Accumulation of aberrations and clonal evolution add complexity to patient management and the assessment of the therapeutic sensitivity profile of malignancies. Liquid biopsy presents a repeatable and minimally invasive assessment tool to detect early …

Publication date: Available online 28 December 2019Source: Seminars in Cancer BiologyAuthor(s): Mohammad Azam Ansari, Muthu Thiruvengadam, Zeba Farooqui, Govindaswamy Rajakumar, Qazi Mohammad Sajid Jamal, Mohammad A. Alzohairy, Ahmad Almatroudi, Mohammad N. Alomary, Ill-Min Chung, Ebtesam Abdullah Al-SuhaimiAbstractBreast cancer is one of the most prevalent and reoccurring cancers and the second most common reason of death in women. Despite advancements in therapeutic strategies for breast cancer, early tumor recurrence and metastasis in patients indicate resistance to chemotherapeutic medicines, such as paclitaxel due to …

More than 67% of people diagnosed with cancer in the United States are alive five years after receiving the diagnosis; but even if they are cancer free, the effects of the disease and its treatment will remain with them for the rest of their lives. Distress, which can be of a psychological, social, physical, or spiritual nature, is common among cancer survivors. Spiritual distress is a broad concept that is not necessarily associated with any specific religious beliefs, practices, or affiliations. Both religious and nonreligious people may have a strong sense of spirituality and may experience spiritual d…

Source: The American Journal of NursingCategory: Nursing Authors: Tags: Am J Nurs Source Type: research

PMID: 31880709 [PubMed – in process]

This study aimed to investigate the expression of Nectin-4 in esophageal cancer tissues compared with adjacent normal esophageal tissue and its association with clinicopathological parameters and prognosis. MATERIAL AND METHODS Nectin-4 expression in esophageal cancer tissues was compared with adjacent normal esophageal tissue from 94 patients using immunohistochemistry, Western blot, and quantitative reverse transcription-polymerase chain reaction (RT-qPCR). The chi-squared (χ²) test and Fisher’s exact test compared categorical variables. The log-rank test and Kaplan-Meier survival analysis assessed the relations…

Long non-coding RNA HULC exerts oncogenic activity on papillary thyroid cancer in vitro and in vivo.
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):326-335
Authors: Yang Z, Li G, Ding C, Sun W, Zhang J
Thyroid cancer is a frequently happened malignancy in human endocrine system. Papillary thyroid cancer (PTC) presents 70-80% of all thyroid cancer cases. Herein, we probed the possible oncogenic function of long non-coding RNA (lncRNA) highly up-regulated in liver cancer (HULC) in PTC. First, the HULC and microRNA-106a (miR-106a) expressions in PTC tissues and cells were tested. Plasmi…

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