Performance of Interleukins 6 and 8, Asp LFD, and Aspergillus PCR in Same-Day Blood and Bronchoalveolar Lavage Fluid Samples

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by Patr ícia Alves de Castro, Ana Cristina Colabardini, Adriana Oliveira Manfiolli, Jéssica Chiaratto, Lilian Pereira Silva, Eliciane Cevolani Mattos, Giuseppe Palmisano, Fausto Almeida, Gabriela Felix Persinoti, Laure Nicolas Annick Ries, Laura Mellado, Marina Campos Rocha, Michael Bromley, Roberto Nasci mento Silva, Gabriel Scalini de Souza, Flávio Vieira Loures, Iran Malavazi, Neil Andrew Brown, Gustavo H. GoldmanAspergillus fumigatus causes invasive aspergillosis, the most common life-threatening fungal disease of immuno-compromised humans. The treatment of disseminated infections with antifungal d…

Source: PLoS GeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Authors: Ikegami H, Yamasaki K, Kawanami T, Fukuda K, Akata K, Nakamura M, Ikushima I, Fukuda Y, Noguchi S, Yatera K
Abstract
A 67-year-old man with a pulmonary cavity was admitted to our hospital. Mycobacterial culture of the bronchoalveolar lavage fluid sample obtained from the right upper pulmonary lesion tested positive for mycobacterium, and sequencing of the 16S rRNA genes, hsp65, and rpoB revealed that the cultured mycobacterium was Mycobacterium parascrofulaceum. Treatment with antimycobacterial agents was ineffective, and repeated culturing of bronchoscopic specimens revealed that the specimens were positi…

Source: Internal MedicineCategory: Internal Medicine Tags: Intern Med Source Type: research

Abstract
Azole antifungals resistance in Aspergillus fumigatus is a worldwide concern. As in most public hospitals in Brazil, antifungal susceptibility tests are not routinely performed for filamentous fungi at our Institution. A 4 years retrospective azole antifungal resistance screening revealed the two azole-resistant A. fumigatus clinical isolates carrying CYP51A TR34/L98H/S297T/F495I mutation resistance mechanism obtained from two unrelated patients. Broth microdilution antifungal susceptibility showed high MICs for Itraconazole, Posaconazole, and Miconazole. STR typing analysis presented high similarity betw…

Source: Antimicrobial Agents and ChemotherapyCategory: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research



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