Royal Belfast Hospital for Sick Children closes ward due to fungus infection

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Aspergillosis is caused by a fungus or mould that can be found in heating or air conditioning systems.

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ConclusionGiven our experience and the literature review, a fungal etiology should be considered early in the course of malignant external otitis unresponsive to a conventional broad spectrum antibiotic therapy, with the need for a tissue biopsy to confirm the diagnosis.

Source: InfectionCategory: Infectious Diseases Source Type: research

Invasive aspergillosis is a fungal infection that occurs mainly in immunocompromised patients. It is responsible for a high degree of mortality and is invariably unresponsive to conventional antifungal treatme…

Source: BMC MicrobiologyCategory: Microbiology Authors: Tags: Research article Source Type: research

Conclusion: We conclude that basophil and lymphocyte activation tests could enhance the diagnosis of allergic mycosis, compared to usual humoral markers. Further studies with larger cohorts and addressing both mold extracts and mold relevant molecules are needed in order to confirm and extend the application of this personalized medicine approach.

Authors: Kanai T, Samejima Y, Noda Y, Kim SH, Tamura K, Umakoshi T, Shimizu K, Kashiwa Y, Morishita H, Ueda K, Kawahara K, Yaguchi T, Matsuoka H
Abstract
Invasive tracheobronchial aspergillosis (ITBA) complicated by nontuberculous mycobacteria (NTM) is rare. An 88-year-old man was admitted for hemoptysis. Bronchoscopy revealed bronchial ulcers, and a tissue biopsy showed Aspergillus fumigatus. He was diagnosed with ITBA, which improved with voriconazole. During treatment, infiltrative shadows appeared in his lungs, and bronchoscopy was performed once again. A non-necrotic epithelioid granuloma and Mycobacterium int…

Source: Internal MedicineCategory: Internal Medicine Tags: Intern Med Source Type: research

In conclusion, our results indicate that S. yanglinensis 3-10 may has a potential to become a promising biofumigant in for control of A. flavus and A. parasiticus.

Subacute invasive pulmonary aspergillosis (SIPA), a rapidly progressive fungal infection of less than three months arising from pre ‐existing lung lesions, generally afflicts moderately immunocompromised patients. We herein report the case of a 69‐year‐old man who developed SIPA following chemoradiotherapy for lung cancer and treated with multiple antifungal therapy. Subacute invasive pulmonary aspergillosis (SIPA), a rapidly progressive fungal infection of less than three months arising from pre ‐existing lung lesions, generally afflicts moderately immunocompromised patients. We herein report the case of a 69‐ye…

Source: Respirology Case ReportsCategory: Respiratory Medicine Authors: Tags: Case Report Source Type: research

Mon, 02/03/2020 – 09:34News blog

Rationale:
Behçet’s disease (BD) is an inflammatory disease that leads to multisystemic immune dysfunction and that involves pulmonary system alterations.
Patient concerns:
A 26-year-old woman presented with dull right chest pain for 30 days and intermittent cough with expectoration for 5 days. She had a history of recurrent oral ulcer and constitutional rash 2 months prior.
Diagnoses:
The patient was diagnosed with BD complicated by IPA and Aspergillus auriculatus infection.
Interventions:
The patient was administered itraconazole oral solution (200 mg b.i.d) to treat the fungal infection. After a diag…

Source: MedicineCategory: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Abstract
Phaeohyphomycosis refers to infections due to a large group of heterogenous organisms called “dematiaceous” or “melanized” fungi. These fungi are distinguished by the predominance of melanin in their cell walls, which likely acts as a virulence factor. Virtually, everyone is exposed to dematiaceous fungi through inhalation, as they are ubiquitous in the environment, although the development of infection is extremely uncommon. Invasive disease is rare but remains important due to the ability to cause serious disease in immunocompetent and immunocompromised hosts, unlike other fungal inf…

Source: Respiratory CareCategory: Respiratory Medicine Authors: Tags: Semin Respir Crit Care Med Source Type: research

Abstract
Invasive pulmonary aspergillosis (IPA) remains difficult to diagnose and to treat. Most common risk factors are prolonged neutropenia, hematopoietic stem cell or solid organ transplantation, inherited or acquired immunodeficiency, administration of steroids or other immunosuppressive agents including monoclonal antibodies and new small molecules used for cancer therapy. Critically ill patients are also at high risk of IPA. Clinical signs are unspecific. Early computed tomography (CT)-scan identifies the two main aspects, angioinvasive and airway invasive aspergillosis. Although CT-scan findings are not fu…

Source: Respiratory CareCategory: Respiratory Medicine Authors: Tags: Semin Respir Crit Care Med Source Type: research



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