Notes from the Field: Carbapenem-resistant Klebsiella pneumoniae with mcr-1 Gene Identified in a Hospitalized Patient

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In December of 2018, Wyoming identified the state’s first case of carbapenem-resistant Enterobacteriaceae (CRE) containing mcr-1, which is a gene that can make bacteria resistant to colistin, a drug that can be the last resort for some multidrug-resistant infections like CRE.

Source: CDC Morbidity and Mortality Weekly ReportCategory: American Health Tags: Antibiotic and Antimicrobial Resistance Carbapenem Resistant Enterobacteriaceae (CRE) MMWR Morbidity & Mortality Weekly Report Carbapenem Resistant Enterobacteriaceae CRE Source Type: news

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ConclusionThis review shows that there is increasing prevalence of β-lactamase producing P. aeruginosa in some countries in the Arab region. This is a major cause of concern as this implies that more and more instances of multidrug resistance are emerging in this area. This leads to an overall negative impact on the health concerns and amounts to increasing difficulty in combating disease. It is recommended that awareness about antibiotic use and abuse be made a priority and measures of curbing unchecked use of prescription antibiotics be put into place. Effective screening methods to detect cases of resistance at the…

Acinetobacter baumannii is a multidrug-resistant (MDR) hazardous bacterium with very high antimicrobial resistance profiles. Outer membrane vesicles (OMVs) help directly and/or indirectly towards antibiotic resis…

Source: BMC MicrobiologyCategory: Microbiology Authors: Tags: Research article Source Type: research

AbstractInfections by multidrug-resistant (MDR) Gram-negative organisms (GN) are associated with a high mortality rate and present an increasing challenge to the healthcare system worldwide. In recent years, increasing evidence supports the association between the healthcare environment and transmission of MDRGN to patients and healthcare workers. To better understand the role of the environment in transmission and acquisition of MDRGN, we conducted a utilitarian review based on literature published from 2014 until 2019.

In conclusion, wastewater effluents from the investigated poultry slaughterhouses exhibited clinically relevant bacteria (E. coli, MRSA, K. pneumoniae, species of the ACB-and E. cloacae-complexes) that contribute to the dissemination of clinically relevant resistances (i.e. bla CTX-M/SHV, mcr-1) in the environment.Importance Bacteria from livestock may be opportunistic pathogens and carriers of clinically relevant resistance genes, as many antimicrobials are used both in veterinary and human medicine. They may be released into the environment from wastewater treatment plants (WWTPs) that are influenced by wastewater from s…

Source: Applied and Environmental MicrobiologyCategory: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research

This study aimed to determine the prevalence, antibiotic resistance patterns and source tracking of clinical C. jejuni isolates from paediatric diarrhoeal patients in Pakistan.MethodsA total of 150 stool samples from children were processed for the presence of C. jejuni using culture, biochemical tests and species-specific PCR. Antibiotic susceptibility of the isolates was determined by the disc diffusion method, and metallo-β-lactamase (MBL) producers were detected using gene-specific PCR. Source tracking was performed using source-predictive PCR.ResultsC. jejuni was present in 54.6% of the processed samples. More th…

Multidrug-resistant Neisseria gonorrhoeae strains are prevalent, threatening gonorrhoea treatment globally, and understanding of emergence, evolution, and spread of antimicrobial resistance (AMR) in gonococci rem…

Source: BMC GenomicsCategory: Genetics & Stem Cells Authors: Tags: Research article Source Type: research

In this study, we report for the first time the isolation of a strain of the recently described novel species Lactococcus petauri, from rainbow trout suffering from lactococcosis. The aim of this study was to determine the complete genome sequence of L. petauri strain LG_SAV_20 and to characterize its antimicrobial resistance and virulence. The genome of L. petauri LG_SAV_20 consists of 2,078,949 base pair (bp) with a GC content of 38.05%, 1950 predicted coding sequence (CDS), and 60 RNAs (51 tRNAs, 3 ncRNAs, and 6 rRNAs). Phylogenetic analysis revealed that L. petauri LG_SAV_20 shares most of its genome with L. garvieae s…

Source: Current MicrobiologyCategory: Microbiology Authors: Tags: Curr Microbiol Source Type: research

ConclusionsThe combination of fosfomycin and doxycycline should be evaluated further with additional LRVREF isolates. In vivo studies should also be performed prior to usage in clinical situations.

This study shows that the ZKIR assay is an accurate, specific and sensitive novel method to detect the presence of Kp in complex matrices, and indicates that Kp isolates from environmental samples differ from clinical isolates.IMPORTANCE The Klebsiella pneumoniae species complex (Kp) includes human and animal pathogens, some of which are emerging as hypervirulent and/or antibiotic resistant strains. These pathogens are diverse and classified into seven phylogroups, which may differ in their reservoirs and epidemiology. Proper management of this public health hazard requires a better understanding of Kp ecology and routes o…

Source: Applied and Environmental MicrobiologyCategory: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research

The spread of drug-resistant bacteria is considered a global public health problem. According to the World Health Organization (World Health Organization [Internet], 2014), it is anticipated that around 10 million people could die from infections with drug-resistant bacteria by 2050. In Japan, in addition to drug-resistant Gram-positive cocci such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, healthcare-associated infections caused by drug-resistant Gram-negative bacilli, including multidrug-resistant Pseudomonas aeruginosa (MDRP) and multidrug-resistant Acinetobacter still rem…



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