Copper Intrauterine Devices Tied to Lower Risk for Cervical Cancer

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WEDNESDAY, March 18, 2020 — Use of copper intrauterine devices (Cu IUDs) is associated with a lower risk for cervical cancer versus use of the levonorgestrel-releasing intrauterine system (LNG-IUS), according to a study published in the February…

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ConclusionThis study aim to better understand the characteristics of some genes and signaling pathways about cervical cancer by bioinformatics, and could provide further research ideas to find new mechanism, more prognostic factors, and potential therapeutic targets for cervical cancer.

Source: Molecular Genetics & Genomic MedicineCategory: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

Authors: Ling W, Yangchun X, Wei W, Qiang W
Abstract
INTRODUCTION: The present study evaluated the effects of the long non-coding RNA (lncRNA) gastric carcinoma high-expressed transcript (GHET1) in cervical carcinoma development.
METHODS: The expression levels of GHET1 and PTEN were measured using in situ hybridisation, immunohistochemistry (IHC) and quantitative reverse transcription PCR assay to investigate their correlations. In an in vitro study, the effects of GHET1 knockdown on the biological activities of SiHa and HeLa cells were evaluated by MTT, flow cytometry, transwell and wound-healing assays and re…

Source: Cancer BiomarkersCategory: Cancer & Oncology Tags: Cancer Biomark Source Type: research

In conclusion, pelvic lymph node status rather than MACC1 SNPs was the only independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.
PMID: 32174779 [PubMed – in process]

Conditions:   Cervical Cancer;   Chemotherapy Intervention:   Drug: Tegafur, Gimeracil and Oteracil Potassium Capsules Sponsor:   Peking Union Medical College Hospital Not yet recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials

Series Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Contributor : Yanan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienscircCDKN2B-AS1 is significantly upregulated circRNA in HPV16 positive cervical cancer tissues comprared with both HPV16 positive and HPV16 negative normal cervical tissues.So we chose it for further study.To explore the mRNA expression profiles following circCDKN2B-AS1 knockdown, we performed RNA sequencing analysis in SiHa cells with or without circCDKN2B-AS1 knockdown.We performed RNA sequencing in two pairs of RNA samples of SiHa cells with or without circCDKN2B-AS1 knockdown.

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Contributors : Lu Zhao ; Yanan ZhangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensTo explore the circRNA expression profiles during the development and progression of cervical cancer, we performed RNA sequencing analysis with ribosomal RNA-depleted in HPV negative normal cervical epithelium, HPV16 positive normal cervical epithelium, HPV16 positive high-grade squamous intraepithelial lesion (HSIL), and HPV16 positive cervical squamous cell carcinoma tissues,6 cases in each group.Totally 66868 circRNAs were identified (Back-spliced junctions reads ≥1)

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

ABSTRACT OBJECTIVES To determine the efficacy and safety of the use of cryotherapy, cold knife or thermocoagulation compared to Loop Electrosurgical Excision Procedure (LEEP) for the treatment of cervical intraepithelial neoplasia. METHODS Systematic review with meta-analysis of randomized controlled trials in women with cervical intraepithelial neoplasia undergoing treatment with cryotherapy, cold knife, or thermo-coagulation compared with LEEP, to estimate its efficacy and safety. The search was conducted on MEDLINE/PUBMED, Cochrane Central Register of Controlled Trials (CENTRAL) and Scopus, until September 2018. RESULTS…

Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative.RESUMEN Introducci ón: La colpocitología y la investigación del ácido desoxirribonucleico (ADN) del virus del papiloma humano (VPH) de alto riesgo son herramientas bien conocidas para la detección de lesiones cervicales, puesto que permiten el diagnóstico precoz del cáncer y sus lesiones precursoras. Objetivo: El objetivo de este estudio es evaluar la capacidad de detecci…



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