Oncotarget Acute promyelocytic leukemia (APL): a review of the literature


(Impact Journals LLC) Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem.The probability of relapse is significantly higher in the high-risk subset of patients undergoing treatment for APL; overall approximately 10-20% of APL patients relapse regardless of their risk stratification.

Related Links:

Authors: Qin Y, Wang Y, Liu D Abstract It has been reported that Kindlin-3 expression is closely associated with progression ofmany cancers and microRNA (miRNA) processing. However, the effects and its precisemechanisms of Kindlin-3 in acute myeloid leukemia (AML) have not been wellclarified. Our study aimed to explore the interaction between Kindlin-3 and miR-4792in AML. In our study, we found that the expression of Kindlin-3 was dramaticallyincreased in AML samples and cell lines, and the miR-4792 level was significantlydown-regulated. Interestingly, the low miR-4792 level was closely associated withup-regulated …

Source: Oncology Research – March 19, 2020Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Fifty ‐two patients with relapsed/refractory acute myeloid leukemia (AML) were treated with clofarabine, cytarabine, and mitoxantrone. The overall response rate (ORR) was 90.4% (complete remission, CR: 69.2%; CR with incomplete hematological recovery, CRi: 21.2%), with 22 CR/CRi patients undergoing allo geneic hematopoietic stem cell transplantation (allo‐HSCT), while in CR; resulting in a 2‐year OS of 84.3% in CR patients and 90% in patients receiving allo‐HSCT. Clofarabine, cytarabine, and mitoxantrone resulted in high ORR and was safe in refractory/relapsed AML. AbstractClofarabine is active in refractory/relaps…

Source: Cancer Medicine – March 19, 2020Category: Cancer & Oncology Authors: Harinder Gill, Rita Yim, Herbert H. Pang, Paul Lee, Thomas S. Y. Chan, Yu ‐Yan Hwang, Garret M. K. Leung, Ho‐Wan Ip, Rock Y. Y. Leung, Sze‐Fai Yip, Bonnie Kho, Harold K. K. Lee, Vivien Mak, Chi‐Chung Chan, June S. M. Lau, Chi‐Kuen Tags: ORIGINAL RESEARCH Source Type: research

Jacqueline Cloos Glucocorticoid (GC) resistance is a crucial determinant of inferior response to chemotherapy in pediatric acute lymphoblastic leukemia (ALL); however, molecular mechanisms underlying this phenomenon are poorly understood. Deregulated splicing is a common feature of many cancers, which impacts drug response and constitutes an attractive therapeutic target. Therefore, the aim of the current study was to characterize global splicing profiles associated with GC resistance and determine whether splicing modulation could serve as a novel therapeutic option for GC-resistant patients. To this end, 38 primar…

Source: Cancers – March 19, 2020Category: Cancer & Oncology Authors: Rocco Sciarrillo Anna Wojtuszkiewicz Irsan E. Kooi Leticia G. Leon Edwin Sonneveld Roland P. Kuiper Gerrit Jansen Elisa Giovannetti Gertjan J.L. Kaspers Jacqueline Cloos Tags: Article Source Type: research

Hematopoiesis is a tightly regulated process that originates from highly specialized cells, hematopoietic stem cells (HSCs). Many cancers can arise and be maintained by malignant stem cells. In acute myeloid leukemia, leukemic stem cells (LSCs) are identified by their immunophenotype, which is partly shared with normal HSCs (CD34+CD38 −). However, LSCs also possess unique immunophenotypic features that can be used to distinguish them from HSCs and therapeutically target them. One such unique immunophenotypic marker is CD123, found to be aberrantly expressed in leukemic stem, progenitor, and blast cells. Thus, CD123 i…

We examined BMI from oncology diagnosis or presentation, through treatment, and into survivorship across the most common cancer types seen in pediatric oncology. Methods: Patients were categorized into three oncologic diagnoses: leukemia and lymphoma (n = 69), neural tumors (n = 80), and non-neural solid tumors (n = 80) at yearly intervals over the course of 11 years. To allow for comparisons across age groups, BMI percentiles were calculated with

Source: Childhood Obesity – March 18, 2020Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research

CONCLUSION: We found plasma exosome-derived microRNA-532 can be used as a novel survival predictor for acute myeloid leukemia. PMID: 32176633 [PubMed – as supplied by publisher]

Source: Cancer Biomarkers – March 18, 2020Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

CONCLUSION: The 3-(acridin-9-ylmethyl)-5-((10-chloroanthracen-9-yl)methylene)thiazolidine-2,4-dione (LPSF/AA-62) presented the most promising results, showing anti-tumor activity in 5 of the 6 cell types tested, especially inhibiting the formation of colonies of prostate tumor cells (DU-145). PMID: 32189590 [PubMed – as supplied by publisher]

This study, therefore, presents markers that could help predict AML relapse and direct therapeutic strategies.

Source: Cancers – March 17, 2020Category: Cancer & Oncology Authors: Elise Aaseb ø Frode S. Berven Sushma Bartaula-Brevik Tomasz Stokowy Randi Hovland Marc Vaudel Stein Ove D øskeland Emmet McCormack Tanveer S. Batth Jesper V. Olsen Øystein Bruserud Frode Selheim Maria Hernandez-Valladares Tags: Article Source Type: research

ifer M. Rohan Previous research suggests that children and adolescents with acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) often have difficulty adhering to complex treatment regimens during the maintenance phase of therapy. Measurement of treatment adherence can be done via objective (e.g., electronic monitoring (EM), pharmacological assays) or subjective methods (patient, parent, or physician reports). This paper provides an illustration of recommended strategies for comparing discrepancies between two objective measures of medication adherence (e.g., behavioral adherence using electronic monitor…

Iron a tiny molecule with huge effects. Our findings showed that iron participates in drug resistance and iron ‐overload can be considered as a risk factor for relapse. In an attempt to minimize the probability of drug resistance and improve the treatment outcomes in children with ALL, it is suggested that patients’ bone marrow iron stores must be assessed during chemotherapy, and the number of blood trans fusions should be carefully monitored. AbstractDrug resistance is a fundamental clinical concern in pediatric acute lymphoblastic leukemia (pALL), and methotrexate (MTX) is an essential chemotherapy drug administered f…

Source: Cancer Medicine – March 16, 2020Category: Cancer & Oncology Authors: Marjan Abedi, Soheila Rahgozar, Abolghasem Esmaeili Tags: ORIGINAL RESEARCH Source Type: research

Source link