Roche announces Venclexta/Venclyxto combination improved overall survival in people with previously untreated acute myeloid leukaemia


Basel, 23 March 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the phase III VIALE-A study met its dual primary endpoints of overall survival and composite complete remission rate (CR + CRi). Venclexta ®/Venclyxto® (venetoclax) in combination with azacitidine, a hypomethylating agent, showed a statistically significant improvement in overall survival in people with previously untreated acute myeloid leukaemia (AML) who were ineligible for intensive induction chemotherapy, compared to azacitidine alone. Safety for Venclexta/Venclyxto plus azacitidine appeared consistent with the known safety profile of these medicines.“Acute myeloid leukaemia remains a challenging blood cancer, with particularly low median survival rates in patients who cannot tolerate intensive chemotherapy given their age or underlying health,” said Levi Garraway, M.D., Ph.D., Roche’s Chief Medical Officer and Head of Global Product Devel opment. “These data validate the benefit that this Venclexta/Venclyxto-based combination can bring to patients and we look forward to discussing the results with health authorities.” Data from the VIALE-A study will be shared with global health authorities and presented at an upcoming medical meeting. Venclexta has previously been granted accelerated approval by the US Food and Drug Administration (FDA) in combination with azacitidine, or decitabine, or low-dose cytarabine for the treatment of people with newly-diagnosed…

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CONCLUSIONS: Our study findings may aid in the development of behavioral interventions targeted to mitigate Black women breast cancer treatment disparities. We found modifiable factors (e.g. communication, satisfaction ratings) that support opportunities for clinicians to better address Black women’s needs regarding adjuvant treatment options. The development of tailored interventions for newly diagnosed Black breast cancer patients on patient related factors in health care are warranted for Black women with lower educational levels.
PMID: 32197898 [PubMed – as supplied by publisher]

The Arkansas Democrat-Gazette made a little history last week in covering a historic threat, the COVID-19 outbreak that has shut down normal social life in the United States and around the globe.

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Context Therapeutics, a Philadelphia biopharmaceutical company focused on hormone-driven cancers, is teaming up with a Chinese biotech firm to advance the development of Context’s lead new drug candidate.

That experimental therapy, called onapristone ER, is being evaluated in mid-stage clinical testing in patients with certain types of ovarian and endometrial cancers.

Context plans to conduct mid-stage clinical testing of onapristone ER in patients with breast cancer later this year.


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Source: Respiratory CareCategory: Respiratory Medicine Authors: Tags: Eur Respir Rev Source Type: research

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Source: Redox BiologyCategory: Biology Source Type: research

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Source: Guardian Unlimited ScienceCategory: Science Authors: Tags: Coronavirus outbreak Europe World news Asia Pacific Australia news New Zealand Refugees UK news Infectious diseases Science Africa Middle East and North Africa Medical research Microbiology Source Type: news

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Source: European UrologyCategory: Urology & Nephrology Source Type: research

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