CRISPR Quashes Cancer in Mice


Gene editing can knock out genes crucial to cervical tumor cells’ survival, researchers report.

Source: The ScientistCategory: Science Tags: The Literature Source Type: news

Related Links:

ConclusionsOur study reveals the need for targeted patient ‐education about the benefits and limitations of follow‐up. In order to meet increasing costs of cancer care, individualized follow‐up procedures adjusted to risk of recurrence and late‐effects in cervical cancer survivors are warranted.

Source: Acta Obstetricia et Gynecologica ScandinavicaCategory: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

AbstractAimThe present study was designed with the aim to predict Pap smear screening beliefs based on Big Five personality traits.DesignThe present cross ‐sectional study was conducted with 235 women over 18 years of age in Tehran (Iran) in 2018.MethodsThe data collection tools included the demographic information questionnaire, Pap Smear Belief Questionnaire (PSBQ) and the 10 ‐item measure of the Big Five personality traits.ResultsPeople with Agreeableness personality trait were more faced with risks and Barriers and factors associated with Pap smear screening beliefs; and those with Conscientiousness personalit…

Source: Nursing OpenCategory: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research

In this study, we report the first-ever clinically occult OPC in an asymptomatic patient discovered through a saliva test. This case relied upon serial measurements of HPV-16 DNA in saliva, which fell to undetectable levels following low morbidity, curative treatment.

In this study, we determined the capacity of the rapid evaporative ionization mass spectrometry (REIMS), also known as intelligent knife (iKnife), to discriminate between healthy, preinvasive, and invasive cervical tissue. Cervical tissue samples…

Source: Proceedings of the National Academy of SciencesCategory: Science Authors: Tags: Biological Sciences Source Type: research

María L. Garza-Rodríguez

Persistent high-risk human papillomavirus (HR-HPV) infections play a major role in the development of invasive cervical cancer (CC), and screening for such infections is in many countries the primary method of detecting and preventing CC. HPV typing can be used for triage and risk stratification of women with atypical squamous cells of undetermined significance (ASC-US)/low-grade cervical lesions (LSIL), though the current clinical practice in Mexico is to diagnose CC or its preceding conditions mainly via histology and HR-HPV detection. Additional informati…

Source: VirusesCategory: Virology Authors: Tags: Article Source Type: research

AbstractObjectiveThis paper aimed to discuss the scope of operation and clinical effects for locally advanced cervical cancer (LACC) after concurrent chemoradiotherapy (CCRT).MethodsWe retrospectively reviewed the records of 444 patients with stages IB2 –IIB cervical cancer who were divided into two groups whether or not they received CCRT before radical operation in our institute from January 2013 to December 2016. Patients’ characteristics, treatments, and outcomes were analyzed.ResultsThe total efficiency (CR  + PR) of the CCRT + operation group was 96.2%. Specifically, the CR rat…

Publication date: Available online 12 March 2020Source: Biomedicine &PharmacotherapyAuthor(s): Hongning Cai, Lin Yan, Nian Liu, Meng Xu, Hongbing Cai

This study aimed to evaluate the clinical value of HR-HPV viral loads to predict the residual/recurrence lesions among women with high-grade squamous lesions or worse ( ≥ HSIL) after surgery. Finally, 301 women who underwent primary screening of cervical cancer using polymerase-chain-reaction-(PCR)-reverse-dot-blot-(RDB) human papillomavirus (HPV) genotyping and cytology assays were enrolled. They received surgery and took HR-HPV viral loads with a BioPerfectus Multiplex Real-Time PCR assay. Colposcopy biopsies were performed in patients with HPV-16/18(+) and/or TCT ≥ ASCUS with HR-HPV(+). The ri…

Source: Medical OncologyCategory: Cancer & Oncology Source Type: research

Authors: Lu F, Cui D, Mu B, Zhao L, Mu P
Tropomodulin-1 (TMOD1) is a key regulator of actin dynamics, which caps the pointed end of actin filaments. TMOD1 has been reported to be involved in several cellular processes, including neurite outgrowth, spine formation and cell migration. Increasing evidence demonstrates that TMOD1 is implicated in several aspects of cancer development. The present study aimed to investigate the role of TMOD1 in cervical cancer. HeLa and CaSki cell lines, derived from human cervical cancer, were used to evaluate the function of TMOD1. Cell motility was measured via a wound-heali…

Source: Oncology LettersCategory: Cancer & Oncology Tags: Oncol Lett Source Type: research

Source link